LEVODOPA AND THE ON-OFF EFFECTInpharma Weekly -doi:10.1007/BF03286573Springer International PublishingInPharma
Critical Review: Effect of Levodopa (L-dopa) medication on speech intelligibility and articulation in individuals with Idiopathic Parkinson's Disorder (IPD) repeated. Four speech-language pathologists evaluated the video-recorded tapes. Each recording was presented once and `off' and `on' samples were...
Irregularities in motor response after continuing levodopa therapy of Parkinson disease (the "on-off effect") were assessed with the addition of l-α-methydopa hydrazine (carbidopa) in a doubleblind study. Thirteen of 20 patients improved while receiving carbidopa and levodopa while only four of ...
Long-lasting effect of levodopa on holmes' tremor Holmes' tremor, also known as rubral or midbrain tremor, is a slow-frequency (typically > Boelmans,Gerloff,Münchau 被引量: 0发表: 0年 Effect of brief levodopa holidays on the short-duration response to levodopa: evidence for tolerance to ...
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine. We evaluated the current status of 131 patients with idiopathic parkinsonism who were receiving levodopa therapy. The residual parkinsonian symptoms and si... Fahn...
Since the publication of the review by Barger on “The Alkaloids of Ergot” (1938), the study of the effects of ergot alkaloids on the central nervous system has changed its focus from the mere prediction of undesirable side effects, such as emesis or...
The dopa dose had been higher throughout the treatment in the patients developing "on-off" symptoms than in those maintaining an even effect, and, furthermore, the initial improvement had been more marked and dyskinesia had appeared earlier and in a higher frequency. The clinical observations in...
In contrast to our previous study, we find no evidence that L-DOPA administration significantly enhances retrieval and that this is mediated by enhancement of the number of vmPFC reactivations. However, additional non-preregistered analyses reveal a beneficial effect of L-DOPA on extinction retrieval...
Levodopa/carbidopa intestinal gel (LCIG; carbidopa/levodopa enteral suspension) has been widely used and studied for the treatment of motor fluctuations in
We studied the effect of pergolide (combined with levodopa) in 17 patients with Parkinson's disease, including 15 with "wearing off" or on-off phenomena, w... A N,Lieberman,Goldstein,... - 《Neurology》 被引量: 45发表: 1984年 Depression and Anxiety in Persons with Parkinson's Disease ...