The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease. Phases of immobility and incapacity associated with depression alternate with jubilant thaws. Both pharmacokinetic and pharmacodynamic factors are involved in its pathogenesis, but...
The On–Off Phenomenon in Parkinson's Disease We studied the response to continuous infusion of levodopa and the effects of meals on the plasma levodopa concentrations and on the clinical response during oral and intravenous administration of the drug. Meals reduced peak plasma ... John G. Nutt...
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine. We evaluated the current status of 131 patients with idiopathic parkinsonism who were receiving levodopa therapy. The residual parkinsonian symptoms and si... Fahn...
Many patients with idiopathic Parkinson's disease treated with levodopa for more than five years develop fluctuations in their clinical response to this drug. Such fluctuations may be unpredictable, but more commonly occur in a regular pattern related to the size and timing of the levodopa dosage....
“On-off” effect of levodopa One caveat though,levodopa doesn’t work all the time. When levodopa begins to take effect, the person who suffers from Parkinson’s disease experiences periods of good symptom control(“on” time), when he or she can move and function well. ...
Table 1 describes the various terms used in the literature to describe “off’ states [6,7]. Table 1. Terms used to describe “Off” states in Parkinson's Disease due to levodopa therapy. Motor Fluctuations/“Offs” • Wearing off or end-of-dose deterioration • On-Off phenomenon/...
Thermally on-off switching polymers for drug permeation and release The "on-off"phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. Morphology of on-off direction-selective ganglion cells in the rabbit retina.
Electroconvulsive therapy in Parkinson's syndrome with " on-off" phenomena During long-term treatment with L-dopa in Parkinson's syndrome "on-off" phenomenon develops in many cases, often entailing considerable therapeutic problem... J Balldin,S Edén,AK Granérus,... - 《Journal of Neural Tr...
The possible mechanism of the "off-on" phenomenon and some suggestions to influence it, are presented. 展开 关键词: Off-On” effect Parkinson disease Levodopa Decarboxylase inhibitor DOI: 10.1007/BF00312550 被引量: 13 年份: 1977
Analytical Currents: A protein's on/off switch analytical currents: a protein's on/off switch None - 《Analytical Chemistry》 被引量: 0发表: 2011年 MicroRNA regulation of a cancer network: Consequences of the feedback loops involving miR-17-92, E2F, and Myc which is a phenomenon ...