3.1.1Oligoclonal bands (OCB) OCBare clonally restrictedIgthat are produced intrathecally by Bcell clonesthat populate theCSFand brain parenchyma in some diseases [72]. As alumbar punctureis usually performed at onset of ADS, the presence orabsenceof OCBs, detected byisoelectric focusing, should ...
BN McLean,D Miller,Ej Thompson.Oligoclonal banding of IgG in CSF,blood-brain barrier function,and MRI findings in patients with sarcoidosis,systemic lupus erythematosus and behcet' s disease involving the nervous system[J].J Neurol Neurosurg Psychiatry,1995,58:548-554....
Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis (MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are locally produced by clonally expanded antigen-experienced B cells and therefore are believed to hold an important clue ...
All patients presented oligoclonal bands of IgG type 2 or 3 in CSF. The comparisons of blood plasma and cerebrospinal fluid S100B protein concentrations in patients with Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis Cerebrospinal fluid analysis was unremarkable, with normal...
Vrethem, M., Kvarnstrom, M., Stenstam, J., Cassel, P., Gustafsson, M., Landtblom, A.M., Ernerudh, J., 2012. Cytokine mapping in cerebrospinal fluid and blood in multiple sclerosis patients without oligoclonal bands. Mult. Scler. 18, 669-673....
Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. We analyzed the leukocyte count, albumin quotient, immunoglobulin G (IgG) index, and oligoclonal bands in the CSF of fingolimod-treated patients with MS... M.C. Kowarik a , H.L. Pell...
A peculiar feature of rheumatoid arthritis patients is that they carry clonally expanded CD4+ and CD8+ cells in the peripheral blood. While the distortion of the repertoire of CD8+ cells has been ascribed to the increase of CD8+CD57+ large granular lymphocytes, often detected in these patients...
Short communication CNS tumours: oligoclonal immunoglobulin D in cerebrospinal fluid and serum Oligoclonal immunoglobulin D bands were detected by isoelectric focusing in 7 out of 25 unconcentrated cerebrospinal fluid (CSF) samples obtained from pati... M Mavra,J Drulovic,Z Levic,... - 《Acta ...
There are multiple links between MS and EBV infection (reviewed in (Haahr and Hollsberg, 2006)): studies of MS- and EBV-epidemiology; prospective and retrospective analyses of EBV-serology; EBV DNA sequences in blood and tissues; the specificity of antibodies amongst oligoclonal bands in MS pa...
Oligoclonal gamma bands were seen in six of the eight patients from whom sufficient CSF was available. The CSF albumin and serum/CSF albumin ratios were normal in all 16 patients, indicating the presence of intact blood-brain barriers. Six of the 16 patients showed increased CSF IgG levels ...