3.1.1Oligoclonal bands (OCB) OCB are clonally restricted Ig that are produced intrathecally by B cell clones that populate the CSF and brain parenchyma in some diseases [72]. As a lumbar puncture is usually performed at onset of ADS, the presence or absence of OCBs, detected by isoelectric...
The article discusses the presence of oligoclonal bands (OBs) in cerebrospinal fluid (CSF) in patients with clinically isolated syndrome (CIS) together with relative absence in peripheral blood. It mentions that the OBs' frequency may vary between 60 percent in patients who suff...
Reprints and permissions About this article Cite this article Kaiser, R., Dörries, R., Lüer, W. et al. Analysis of oligoclonal antibody bands against individual HIV structural proteins in the CSF of patients infected with HIV. J Neurol 236, 157–160 (1989). https://doi.org/10.1007/BF...
Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct We sought to determine whether Swedish patients with (MS) with and without oligoclonal bands (OCBs) in the constitute distinct subpopulations, clinically a... K Imrell,AM Landtblom,J Hillert,....
Non-specific MRI, blood and (other) CSF abnormalities were also more common, emphasising the need for continued diagnostic vigilance, although the incautious application of McDonald diagnostic criteria in OCB negative cases renders categorisation as 鈥樷definite鈥欌 MS more likely. Studying the ...
All patients presented oligoclonal bands of IgG type 2 or 3 in CSF. The comparisons of blood plasma and cerebrospinal fluid S100B protein concentrations in patients with Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis Cerebrospinal fluid analysis was unremarkable, with normal...
BN McLean,D Miller,Ej Thompson.Oligoclonal banding of IgG in CSF,blood-brain barrier function,and MRI findings in patients with sarcoidosis,systemic lupus erythematosus and behcet' s disease involving the nervous system[J].J Neurol Neurosurg Psychiatry,1995,58:548-554....
Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent a hallmark of multiple sclerosis (MS), where they can be detected in > 90% of cases and support its diagnosis,...
This study investigates the occurrence of oligoclonal bands (OCBs) in the CSF of a large series of ALS patients, attempting a correlation with genotype data. CSF was collected from 259 ALS patients. CSF parameters were measured according to standard procedures, and detection of OCBs performed by...
Just why the oligoclonal bands are present in the patterns for sera of patients with multiple sclerosis has not been determined, but if the criterion of oligoclonal bands in CSF and not in serum is used to determine clinical significance, this may lead to false-negative results. References 1...