The increase in the IgG/albumin ratio and the presence of oligoclonal bands in CSF from MS patients now serve as important tools in the diagnosis of MS. Although a small percentage of patients with other neurologic disorders also demonstrate oligoclonal bands, electrophoresis of CSF is the ...
The presence of oligoclonal IgG bands in human CSF during the course of neurological diseases. Journal of neurology. 2014; 261(3):554-560. [PubMed: 24449061]Haertle M, Kallweit U, Weller M, Linnebank M. The presence of oligoclonal IgG bands in human CSF during the course of neuro- ...
established five classical patterns in CSF and paired serum samples, being the type 2 and 3 corresponding to the diagnosis of MS (Table 6, Fig. 1). However, they did not mention the cut off for the number of bands detected in CSF by the IEF technique [41]. It is not until the ...
Schmidt RM, Neumann V. CSF-oligoclonal bands in multiple sclerosis. Schweiz Arch Neurol Neurochir Psych 1978; 123: 321-9.Procaccia S., Caputo D. : Oligoclonal bands in multiple sclerosis . Progress in M.S. Research Ed. by H.J. Bauer, S. Poser, G. Ritter- Springer Berlin 1980...
The specificity for GFAP (glial fibrillary acidic protein) of oligoclonal IgG bands in the CSF of a patient with acute myelitis was demonstrated by isoelectric focusing and affinity blotting. Findings were confirmed by western blotting using a monoclonal antibody to GFAP as a reference. Immune react...
Since some neurological disorders present with increased body-mass index (BMI) and cerebrospinal fluid (CSF) oligoclonal bands (OCB), obesity-induced inflammation has been previously speculated in formation of OCB. We investigated the association between BMI, OCB formation and clinical features of MS...
"The most important addition is that the new criteria allow MS diagnosis when the MRI scan meets criteria for DIS and unique oligoclonal bands (OCB) are present in [cerebrospinal fluid], even in absence of DIT on the MRI scan," the researchers wrote. New multiple sclerosis criteria may crea...
Once present, CSF OB persists in the individual patient irrespective of MS course or therapy. Because of the high sensitivity of CSF OB in MS as well as its high specificity in the appropriate clinical setting, examination of CSF for OB of IgG class can be strongly recommended to obtain ...
in these CNS infections and inflammatory diseases, the presence of 10 or more bands is usually more frequently observed in MS.14Once present, OCB persist in the CSF of MS patients, pointing to a stable B-cell–mediated intrathecal immune response in MS. The sensitivity of OCB detection in ...
Although the presence of OCBs in CSF of MS patients is now well established as a sensitive laboratory test to support the clinical diagnosis, OCBs may be present in other disorders, including those not directly related to infection or abnormal immune response. Nevertheless, the pathogenesis of ...