Mirtazapine does not affect gastric accommodation based on barostat measurements, suggesting a predominantly central mode of action [96]. Mirtazapine is effective for postoperative nausea and vomiting based on meta-analysis of RCTs [97]. Benefit of mirtazapine has been shown from case reports of ...
Olanzapine (Olz) is an atypical antipsychotic whose mode of action remains unclear. We determined the effect of Olz on PV-positive ( ) and glutamate decarboxylase 67 (GAD67) cell numbers in the layers of dorsal hippocampus (dHIPP) cornu ammonis (CA1鈥揅A3) and dentate gyrus...
Olanzapine (Olz) is an atypical antipsychotic whose mode of action remains unclear. We determined the effect of Olz on PV-positive ( ) and glutamate decarboxylase 67 (GAD67) cell numbers in the layers of dorsal hippocampus (dHIPP) cornu ammonis (CA1–CA3) and dentate gyrus (DG) ...
Therefore, it appears that both assumptions partially reproduced the results of thein vitronetwork activity measurements. To mimic the effects of the antipsychotics more precisely in thein silicosystem, the “Mixed” assumption was tested (Fig.2f). The “Mixed” assumption proposes that half of the ...
A possible participation of the renin-angiotensin system (RAS) components with mood disturbances has been suggested in both animal and pharmacological mode... IV Meira-Lima,AC Pereira,GFA Mota,... - 《Neuroscience Letters》 被引量: 78发表: 2000年 Tolerability profile of atypical antipsychotics in...
Compared with the controls, the patients at baseline exhibited increased long-range positive FCS (lpFCS) in the bilateral inferior parietal lobule (IPL) and decreased lpFCS in the brain regions of the default-mode network (DMN) regions and sensorimotor circuits of the brain. By contrast, ...
Single electrode voltage-clamp (holding potential À60 mV) was performed in the discontinuous mode with a sampling rate of 5–6.2 kHz. The voltage-clamp recordings were acquired using digital/analogue sampling and acquisi- tion software (Clampex version 9.2, Molecular Devices). During the voltage...
was run in positive ion ESI mode using multiple-reaction moni- toring (MRM) to monitor the mass transitions. Nitrogen gas was used as the desolvation gas and was set to a flow rate of 500 l/h with a temperature of 350 ◦ C. The cone gas flowwas set to 50 l/h. Argon was...
Ritanserin was used to determine the 5-HT receptor mode of action. RESULTS: A single dose of 10 mmol/kg OLZ produced no change in rat brain cortex PLD activity, 20 mmol/kg OLZ caused a nonsignificant decrease, and long-term (21 days) administration of OLZ resulted in a 41.9% ...
Olanzapine can affect amygdalar and hippocampal neuronal populations by the modulation of neuropeptide activity. Importantly, it may suggest the existence of an alternative mode of its action. Undoubtedly this hypothetic regulatory mechanism requires further pharmacological and neurostructural study....