Olanzapine (Oz) and haloperidol (Hp) modify the density of excitatory and inhibitory synapses to excitatory and inhibitory neurons. (a) The principle of the synapse quantification method is based on the detection of presynaptic and postsynaptic markers. (b) The overlap between presynaptic and postsyn...
agent in the management of newly diagnosed psychosis. It has a similar mechanism of action to classical antipsychotics but with a lower incidence of adverse events. O lanzapine rarely produces hypotension and has less potential for QT prolongation. It is used in the management of delirium in ICU...
Conclusion: QUE and OLA, contrary to the prooxidative action of HAL, did not induce oxidative stress; moreover, QUE has antioxidant properties. 展开 关键词: Oxidative stress Lipid peroxidation Antipsychotics Quetiapine Olanzapine Haloperidol DOI: 10.1159/000321623 ...
Mirtazapine does not affect gastric accommodation based on barostat measurements, suggesting a predominantly central mode of action [96]. Mirtazapine is effective for postoperative nausea and vomiting based on meta-analysis of RCTs [97]. Benefit of mirtazapine has been shown from case reports of ...
Furthermore, the orexigenic action of olanzapine, which is considered a side effect of the drug,24 can be expected to maintain appetite and mood during chemotherapy in patients with cancer. Considering the results of dietary intake and subjective estimations of nausea and vomiting during chemotherapy...
cognition and greater incidence of receiving an improved clinical diagnosis. Because imipramine and olanzapine are completely different drugs with regard to their structures, designed mechanisms of action, and current approved clinical indications, and their only common link is our discovery of their ...
cognition and greater incidence of receiving an improved clinical diagnosis. Because imipramine and olanzapine are completely different drugs with regard to their structures, designed mechanisms of action, and current approved clinical indications, and their only common link is our discovery of their ...
targetcompartmentfortherapeuticaction,andcognitivefunc- tion.Accuratemeasurementsofantipsychoticlevelsinbrain tissuewillalsofacilitatemorepreciseestimatesofdopamine ∗ Correspondingauthor.Tel.:+17065425390;fax:+17065425358. E-mailaddress:bartlett@rx.uga.edu(M.G.Bartlett). D2receptoroccupancy,afactorthathasbeensug...
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action J. Biol. Chem., 277 (2) (2002), pp. 1531-1537, 10.1074/jbc.M101521200 View PDFView articleView in ScopusGoogle Scholar [38] G. Tuncman, J. Hirosumi, G. So...
In addition, the combined chronic treatment of rats with fluoxetine and olanzapine led to increased FGF-2 levels in different brain regions, as well as the phosphorylation of Akt in the prefrontal cortex, thus suggesting the involvement of this signaling pathway in the mechanism of action of such...