Schizophrenia is a disabling and chronic disorder associated with severe social, occupational, and quality of life (QOL) impairments. Olanzapine (Olz), an atypical antipsychotic, has demonstrated improved clinical efficacy compared with haloperidol (Hal), but little is known on Olz's impact on QOL...
O lanzapine is classed as an atypical antipsychotic and is considered a firstline agent in the management of newly diagnosed psychosis. It has a similar mechanism of action to classical antipsychotics but with a lower incidence of adverse events. O lanzapine rarely produces hypotension and has les...
agent in the management of newly diagnosed psychosis. It has a similar mechanism of action to classical antipsychotics but with a lower incidence of adverse events. O lanzapine rarely produces hypotension and has less potential for QT prolongation. It is used in the management of delirium in ICU...
Allopregnanolone induction may contribute to olanzapine and clozapine anxiolytic, antidepressant, and mood-stabilizing actions. Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy. This is a ...
In some cases, the events correlated with a rapid, greater than expected increase in serum olanzapine concentrations to supratherapeutic ranges, but the mechanism by which the drug entered the bloodstream is not known.Manifestations of PDSS include dizziness, confusion, disorientation, malaise, slurred...
Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors. Psychopharmacology (Berl). 2009;207(1):119-12519688201PubMedGoogle ScholarCrossref 55. Rauser L, Savage JE, Meltzer HY, Roth BL. Inverse agonist actions of typical and atypical antipsychotic drugs at the ...
To understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (TRD), we studied ... WZ Md,D Ph. - 《Neuropsychopharmacology》 被引量: 400发表: 2000年 Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production...
In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Prog Brain Res 172: 177–197. Moghaddam B, Bunney BS (1990). Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of ...
of ovarian secretion, adrenal synthesis appears to be functionally significant in rodents (Feder and Ruf, 1969;Walker et al, 2001) and may be relevant to nonreproductive functions in both males and females. For example, recent evidence suggests that progesterone actions contribute to central nervous...
However, the exact mechanism(s) of action responsible for the clinical benefits of olanzapine plus fluoxetine combination therapy in patients with bipolar depression is unclear at present, although it has been proposed to involve the activation of serotonin, dopamine and noradrenaline neural systems. ...