Schizophrenia is a disabling and chronic disorder associated with severe social, occupational, and quality of life (QOL) impairments. Olanzapine (Olz), an atypical antipsychotic, has demonstrated improved clinical efficacy compared with haloperidol (Hal), but little is known on Olz's impact on QOL...
Suicidal Thoughts or Actions. Olanzapine/fluoxetine or other antidepressants may increase the risk of suicidal thoughts or actions in a small number of children, teenagers, or young adults. The risk is higher in the first few months of taking the medicine or when the dose is changed. Depression...
agent in the management of newly diagnosed psychosis. It has a similar mechanism of action to classical antipsychotics but with a lower incidence of adverse events. O lanzapine rarely produces hypotension and has less potential for QT prolongation. It is used in the management of delirium in ICU...
allopregnanolone. Allopregnanolone induction may contribute to olanzapine and clozapine anxiolytic, antidepressant, and mood-stabilizing actions. Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy...
To understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (TRD), we studied ... WZ Md,D Ph. - 《Neuropsychopharmacology》 被引量: 399发表: 2000年 Atypical antipsychotic drugs induce derangements in glucose homeostasis by ...
In some cases, the events correlated with a rapid, greater than expected increase in serum olanzapine concentrations to supratherapeutic ranges, but the mechanism by which the drug entered the bloodstream is not known.Manifestations of PDSS include dizziness, confusion, disorientation, malaise, slurred...
Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors. Psychopharmacology (Berl). 2009;207(1):119-12519688201PubMedGoogle ScholarCrossref 55. Rauser L, Savage JE, Meltzer HY, Roth BL. Inverse agonist actions of typical and atypical antipsychotic drugs at the ...
Interestingly, the present study added another piece of evidence for the dissociated anxiolytic and antipsychotic actions of OLZ and CLZ, as both OLZ-induced sensitization and CLZ-induced tolerance were selective to their putative antipsychotic effect (eg, anti-avoidance) and not to their anxiolytic...
4 However, it is still difficult to prevent CINV induced by HEC or moderately emetogenic chemotherapy (MEC) in the delayed phase (24–120 hours after the initiation of chemotherapy). The mechanism underlying the discrepancy in antiemetic effects between the acute and delayed phases is not clearly...
In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Prog Brain Res 172: 177–197. Moghaddam B, Bunney BS (1990). Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of ...