We identified a previously undescribed mechanism for activation of tyrosine kinases in cancer: the formation of episomes resulting in a fusion between NUP214 and ABL1. We detected the NUP214-ABL1 transcript in five individuals with the ABL1 amplification, in 5 of 85 (5.8%) ...
5,6). We identified a previously undescribed mechanism for activation of tyrosine kinases in cancer: the formation of episomes resulting in a fusion between NUP214 and ABL1. We detected the NUP214-ABL1 transcript in five individuals with the ABL1 amplification, in 5 of 85 (5.8%) additional...
Few reports have indicated potential anti-leukemic activity for dasatinib in patients with B-cell ALL harboring NUP214-ABL1 fusion, however, in these cases, dasatinib was administered in combination with other chemotherapeutic agents [2,8].
Molecular analysis demonstrated the oncogenic fusion of ABL1 with the nuclear pore complex protein NUP214 (NUP214-ABL1). We screened 29 pts with T-cell lymphoblastic lymphoma (T-LBL) and T-ALL for the presence of the NUP214-ABL1 fusion transcript by RT-PCR using specific primers for the...
(lane 3) and BE-13 (lane 4) cells is also shown. (B) NUP214-ABL1-positive cells were also demonstrated by FISH using a specific NUP214-ABL1 red/green fusion probe in a bone marrow specimen obtained from Patient 2 at the same time point. Experiments were performed as described in ...
NUP214-ABL1 fusioncomplex karyotypeepisomesintra-tumor genetic heterogeneitymolecular cytogeneticsarray comparative genomic hybridizationT-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin's lymphoma and little is known about their molecular background. However, complex karyotypes...
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. Leukemia. 2009; 23(1):125- 133. [PubMed: 18923437]Graux C,Stevens-Kroef M,Lafage M,et al.Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute...
Intrinsic differences between the catalytic properties of the oncogenic NUP214- ABL1 and BCR-ABL1 fusion protein kinases. Leukemia 2008; 22: 2208-2216.De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O. Intrinsic differences between the catalytic properties of the oncogenic ...
The NUP214-ABL1 fusion protein is a constitutively active protein tyrosine kinase that is found in 6% of patients with T-cell acute lymphoblastic leukemia and that promotes proliferation and survival of T-lymphoblasts. Although NUP214-ABL1 is sensitive to ABL1 kinase inhibitors, development of ...
Here, we describe an extremely rare case of Philadelphia chromosome-like T-cell acute lymphoblastic leukemia (Ph-like T-ALL) with NUP214-ABL1 fusion and presentation of unusually enlarged nuclei in the leukemic cells, which was attributed to tetraploidy. Despite receiving the protocol-guided ...