NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance. Leukemia, 19 (3), 468–470.Ballerini, P. , Busson, M. , Fasola, S. , Van Den Akker, J. , Lapillonne, H. , Romana, S.P. , Marynen, P. , Bernard,...
We detected the NUP214-ABL1 transcript in five individuals with the ABL1 amplification, in 5 of 85 (5.8%) additional individuals with T-ALL and in 3 of 22 T-ALL cell lines. The constitutively phosphorylated tyrosine kinase NUP214-ABL1 is sensitive to the tyrosine kinase inhibitor imatinib7...
Response to single agent dasatinib post allogeneic transplant in B-cell acute lymphoblastic leukemia with NUP214-ABL1Response to single agent dasatinib post allogeneic transplant in B-cell acute lymphoblastic leukemia with NUP214-ABL1The majority of Philadelphia-like (Ph-like) acute lymphoblastic leukemi...
In this case report, we present the diagnosis of a Ph-like T-ALL case with NUP214-ABL1 fusion, which was complicated by the presence of unusually enlarged nuclei in the leukemic cells. The nuclear phenotype was ultimately attributed to tetraploidy....
本发明属于疾病基因检测的领域,特别是涉及采用探针实时荧光pcr技术对人类急性t淋巴细胞白血病中nup214-abl1的表达量进行检测的试剂盒和方法。 技术背景 急性t淋巴细胞白血病(t-cellacutelymphoblasticleukemia,t-all)是一种以t淋巴细胞恶性克隆性增殖为特征的血液系统肿瘤,发病率占急性淋巴细胞白血病(acutelymphoblasticleukem...
NUP214-ABL1 fusioncomplex karyotypeepisomesintra-tumor genetic heterogeneitymolecular cytogeneticsarray comparative genomic hybridizationT-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin's lymphoma and little is known about their molecular background. However, complex karyotypes...
Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia. Leukemia. 2006; 20 :2202–2204.De Keersmaecker K, Lahortiga I, Graux C, Marynen P, Maertens J, Cools J, Vandenberghe P. Transition from EML1- ABL1 to NUP214-A...
包括PCR反应液,所述PCR反应液包括用于扩增NUP214‑ABL1融合基因的引物和探针。该试剂盒经测试特异性好,灵敏度高,操作简便。有助于临床上急性T淋巴细胞白血病患者体内NUP214‑ABL1融合基因的检测,对于调整治疗方案、评价治疗效果、预测预后、预防临床复发都具有重要意义。
NUP214::ABL1: A Ph-like fusion found in a pediatric acute myeloid leukemia patient with normal karyotypedoi:10.1002/pbc.30203Fernanda de Oliveira MotaFrancine Tesser GambaMichele Gaboardi de Carvalho PiresSilva Regina Caminada de ToledoJuliana Thomazini Gouveia...
Quintas-Cardama A, Tong W, Manshouri T, Vega F, Lennon PA, Cools J, et al. Activity of tyrosine kinase inhibitors against human NUP214-ABL1-positive T cell malignancies. Leukemia 2008;22:1117-24.Quintas-Cardama A, Tong W, Manshouri T, Vega F, Lennon PA, Cools J et al. Activity ...