Molecular analyses delineated the amplicon as a 500-kb region from chromosome band 9q34, containing the oncogenes ABL1 and NUP214 (refs.(5,6)). We identified a previously undescribed mechanism for activation of tyrosine kinases in cancer: the formation of episomes resulting i...
Molecular analyses delineated the amplicon as a 500-kb region from chromosome band 9q34, containing the oncogenes ABL1 and NUP214 (refs. 5,6). We identified a previously undescribed mechanism for activation of tyrosine kinases in cancer: the formation of episomes resulting in a fusion between ...
Few reports have indicated potential anti-leukemic activity for dasatinib in patients with B-cell ALL harboring NUP214-ABL1 fusion, however, in these cases, dasatinib was administered in combination with other chemotherapeutic agents [2,8].
Unit Size 1ug Concentration Download for COA Purity Download for COA RNA electrophoresis Download for COA Sanger sequencing Storage -80℃ Expiry 12 months from the date of manufacture 上一篇: BCR(E13)-ABL1(E2)_P210 Fusion 下一篇: EML4(E13)-ALK(A20) with p.G1296A Fusion 相关文...
Molecular analysis demonstrated the oncogenic fusion of ABL1 with the nuclear pore complex protein NUP214 (NUP214-ABL1). We screened 29 pts with T-cell lymphoblastic lymphoma (T-LBL) and T-ALL for the presence of the NUP214-ABL1 fusion transcript by RT-PCR using specific primers for the...
结论 该患者为极其罕见的SET-NUP214融合基因阳性,且伴有粒细胞肉瘤的MPAL.%Objective To study the features of a patient with mixed phenotype acute leukemia with SETNUP214 fusion gene and myeloid sarcoma.Methods Pathological biopsy,bone marrow morphology,flow cytometry are performed and karyotyping,...
) and BE-13 (lane 4) cells is also shown. (B) NUP214-ABL1-positive cells were also demonstrated by FISH using a specific NUP214-ABL1 red/green fusion probe in a bone marrow specimen obtained from Patient 2 at the same time point. Experiments were performed as described in Example 1....
NUP214-ABL1 fusioncomplex karyotypeepisomesintra-tumor genetic heterogeneitymolecular cytogeneticsarray comparative genomic hybridizationT-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin's lymphoma and little is known about their molecular background. However, complex karyotypes...
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. Leukemia. 2009; 23(1):125- 133. [PubMed: 18923437]Graux C,Stevens-Kroef M,Lafage M,et al.Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute...
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet. 2004;36:1084-1089.Stergianou K, Fox C, Russell NH. Fusion of NUP214 to ABL1 on amplified episomes in T-ALL - implications for treatment. Leukemia 2005;19:1680-1681....