The NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia (T-ALL) has recently been identified as a possible target for imatinib and related tyrosine kinase inhibitors, but exact data regarding the prognostic impact and frequency of the several putative NUP214-ABL1 mRNA transcripts are ...
NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance. Leukemia. 2005; 19 :468–470.Ballerini P, Busson M, Fasola S et al. NUP214-ABL1 amplification in t(5; l4)/HOXllL2-positive ALL present with several forms ...
We detected the NUP214-ABL1 transcript in five individuals with the ABL1 amplification, in 5 of 85 (5.8%) additional individuals with T-ALL and in 3 of 22 T-ALL cell lines. The constitutively phosphorylated tyrosine kinase NUP214-ABL1 is sensitive to the tyrosine kinase inhibitor imatinib7...
The recurrent cryptic NUP214-ABL1 rearrangement is associated with increased HOX expression1 and deletion of CDKN2A9, consistent with a multistep pathogenesis of T-ALL. NUP214- ABL1 expression defines a new subgroup of individuals with T-ALL who could benefit from treatment with imatinib. The ...
本发明属于疾病基因检测的领域,特别是涉及采用探针实时荧光pcr技术对人类急性t淋巴细胞白血病中nup214-abl1的表达量进行检测的试剂盒和方法。 技术背景 急性t淋巴细胞白血病(t-cellacutelymphoblasticleukemia,t-all)是一种以t淋巴细胞恶性克隆性增殖为特征的血液系统肿瘤,发病率占急性淋巴细胞白血病(acutelymphoblasticleukem...
Ph-like (or BCR-ABL1 -like) ALL does not express BCR-ABL1 but commonly harbors other genomic alterations of signaling molecules that may be amenable to therapy. Here, we report a case with a NUP214-ABL1 fusion detected at relapse by multiplexed, targeted RNA sequencing. It had escaped ...
NUP214::ABL1: A Ph-like fusion found in a pediatric acute myeloid leukemia patient with normal karyotypedoi:10.1002/pbc.30203Fernanda de Oliveira MotaFrancine Tesser GambaMichele Gaboardi de Carvalho PiresSilva Regina Caminada de ToledoJuliana Thomazini Gouveia...
NUP214-ABL1 fusioncomplex karyotypeepisomesintra-tumor genetic heterogeneitymolecular cytogeneticsarray comparative genomic hybridizationT-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin's lymphoma and little is known about their molecular background. However, complex karyotypes...
We detected the NUP214-ABL1 transcript in five individuals with the ABL1 amplification, in 5 of 85 (5.8%) additional individuals with T-ALL and in 3 of 22 T-ALL cell lines. The constitutively phosphorylated tyrosine kinase NUP214-ABL1 is sensitive to the tyrosine kinase inhibitor imatinib(...
Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia. Leukemia. 2006; 20 :2202–2204.De Keersmaecker K, Lahortiga I, Graux C, Marynen P, Maertens J, Cools J, Vandenberghe P. Transition from EML1- ABL1 to NUP214-ABL1 positivity in a...