upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach. Nrf2(NF-E2 相关因子-2)转录因子能调节氧化/异生物应激反应,还能抑制炎症。然而,Nrf2如何缓解炎症的机制仍不清楚。在这里,我们证明了Nrf2能干扰脂多糖诱导的促炎细胞因子(包括IL-6和IL-...
[34].Kobayashi E.H., et. al.: Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat. Commun. 2016; 7: pp. 11624. 秀出你的医学笔记活动正式启动!快来围观医学生的笔记本
cytoprotective pathways, with Nrf2 serving as a master transcriptional regulator of the basal and inducible expression of a multitude of genes encoding detoxification enzymes, anti-oxidant proteins, xenobiotic transporters, anti-apoptotic proteins, anti-inflammatory cytokine and many other stress-response ...
Infusion of melatonin into the paraventricular nucleus ameliorates myocardial ischemia- reperfusion injury by regulating oxidative stress and inflammatory cytokine[s J]. J Cardiovasc Pharmacol, 2019, 74(4): 336-47. [24]Dodson M, de la Vega MR, Cholanians AB, et al. Modulating NRF2 in disease...
anti-inflammatory cytokine and many other stress-response mediators. Liver and kidney injury, induced by some stimuli, could be repaired by the regulation of endogenous and exogenous stresses, apoptosis, inflammatory and oxidative stress. This review provides an update on the mechanism and highlights ...
cytokine withdrawal‑induced death sensitivity of effector T cells derived from distinct human CD8+ memory subsets”,2017.Cell Death Discov.2017;3:17031. [0356]Lei,X.G.,et al.,“Paradoxical Roles of Antioxidant Enzymes:Basic Mechanisms and Health Implications”,Physiol Rev,2016.96(1):p.307‑...
Pg LPS, nicotine, and 4-NQO induce oxidative stress and regulate anti-oxidative response and cytokine expressions in human gingival keratinocytes differently. These results may indicate that bacterial and tobacco-related insults regulate distinct pathways....
[47] E.H. Kobayashi, T. Suzuki, R. Funayama, T.Nagashima, M. Hayashi, H. Sekine, N. Tanaka, T. Moriguchi, H. Motohashi, K.Nakayama, M. Yamamoto, Nrf2 sup- presses macrophage inflammatoryresponse by blockin...
Cytokine, 2014, 69(1): 29-38. [24]Fathi H, Ebrahimzadeh MA, Ziar A, et al. Oxidative damage induced by retching; antiemetic and neuroprotective role of Sambucus ebulus L[J]. Cell Biol Toxicol, 2015, 31(4/5): 231-9. [25]Kim KC, Lee IK, Kang KA, et al. Baicalein (5, 6,...
To ascertain Nrf2 dependency of the inhibition of proinflammatory cytokine gene induction, we tested the consequences of chemical induction of Nrf2. For the pharmacological activation of Nrf2, we used two small molecule inducers: diethylmaleate (DEM), an electrophilic reagent, and 15-deoxy-Δ12,14-...