Leal, V.O., J.F. Saldanha, M.B. Stockler‑Pinto, L.F.M.F Cardozo and F.R. Santos et al., 2015. NRF2 and NF‑6B mRNA expression in chronic kidney disease: A focus on nondialysis patients. Int. Urol....
从机制上讲,已经提出了 NSAID 的几种不依赖 COX 的作用,包括抑制NF-κB(Inhibition of NF-kappa B by sodium salicylate and aspirin. Science)和炎症小体(Non-steroidal anti-inflammatory drugs are caspase inhibitors. Cell Chem. Biol),以及无数其他潜在的脱靶途径(Small molecule interactome mapping by photoa...
Nuclear factor-kappa B (NF-B) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-B expression and IB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and...
老年猕猴颈动脉血管的氧化应激反应明显不如年轻猕猴.H2O2和高糖环境,年轻猕猴血管平滑肌细胞(VSMCS) Nrf2调控基因表达水平明显增加,而老年猕猴Nrf2/ARE通路激活较弱.在大鼠实验中也发现了相似结果,老龄大鼠血管Nrf2活性和Nrf2靶基因的表达降低以及NF-κB靶基因的表达增加.老化对Nrf2功能损伤是一种恶性循环,加剧了...
核因子κB (Nuclear factor kappa-B, NF-κB)是第一个在B淋巴细胞前体细胞核中发现的蛋白7。大量研究证明,NF-κB是炎症反应过程中至关重要的转录因子,介导炎症介质的表达8。核因子红细胞-2相关因子2 (Nuclear factor erythroid-2 related factor 2, Nrf2)是氧化应激反应的核心调节因子。一旦被激活,它将转移到细...
http://wwwidforg/whoweare [2]迟家敏 实用糖尿病学[M] 北京:人民卫生出版社, 2015 [3]Ferdinando Giacco, Michael Brownlee Oxidative stress and diabetic complications[J] Circ Res, 2010(107): 1058 [4]Matsushita H,Morishita R, Nata T, et al Hypoxiainduced endothelial apoptosis through NFkappa B...
例如,子宫内膜炎是发生着床障碍的主要病因之一,内膜炎症影响蜕膜化在临床研究中也得到了验证[34],一方面,炎症触发ROS过度堆积导致子宫内膜细胞氧化应激损伤,另一方面核因子-κB(nuclear factor kappa-B,NF-κB)等炎症信号通路激活会产生综合影响[35]。...
3.3.2NF-κB The transcription factor nuclear factor-kappa B (NF-κB) is activated by many different stimuli, binds to specificDNA sequencesin target genes, and regulates the transcription of genes involved inimmunoregulation, growth regulation, inflammation, carcinogenesis, andapoptosis[91]. Many repo...
Osteoclastogenesis is regulated by Receptor activator of nuclear factor kappa-β ligand (RANKL) produced by osteoclastogenesis supporting cells such as osteoblast and osteocyte. Previously, we reported that NF-E2-related factor-2 (Nrf2) activation in osteoclast precursors inhibited osteoclastogenesis and ...
One such factor is B-cell activating factor (BAFF), a cytokine that is produced mainly by nurse-like cells (NLC) and enhances CLL cells survival and modulates response to therapy. In CLL cells, BAFF activates NF-κB signaling, but how NF-κB supports CLL survival is not entirely clear. ...