Therefore, the Nrf2 pathway may be a potential therapeutic target for SCI. This review deeply analyzed the generation of oxidative stress in SCI, the role and mechanism of Nrf2 as the main regulator of antioxidant stress in SCI, and the influence of cross-talk between Nrf2 and related pathways...
Nrf2 Signaling Pathway Studies in Drosophila melanogaster: Parallel Roles in Human Health and Insect Environmental Responses Jingyi LiShushen SunYing LiMengzhe TianXinyi LiSuxia RenZengyi HuangYiwen WangShaoshan Du
1.Then we study the effct of TNF-α, IL-1βand PMA on the NF-κB and Nrf2 pathway, and found that the three stimulus have slight negative regulation of the Nrf2 pathway while activiting the NF-κB pathway.以此为出发点,本研究探讨了NF-κB通路和Nrf2通路之间的交互关系。 英文短句/例句 1....
Genc, K. Genc, The Nrf2/ARE pathway: a prom- ising target to counteract mitochondrial dysfunction in Parkinson's disease, Parkinson's Dis. 2011 (2011) 314082.Tufekci K U, Civi Bayin E, Genc S, et al. The Nrf2/ ARE pathway: a promising target to counteract mitochondrial dysfunction in ...
DOI :https://doi.org/10.1093/abbs/gmaa013 Article index updated : Feb 15, 2025 Altmetric score(what's this?) 8 CITATIONS 8 Crossref 7 Web of Science Source article Related records 7 Scopus 1092 Article access Explanation of terms and methodology ...
Epithelial mesenchymal transition (EMT) is a key progression that promotes pulmonary fibrosis (PF). Numb, a phosphotyrosine-binding domain (PTB) protein, is implicated with EMT. Nuclear factor erythroid 2-related factor2 (Nrf2) and its downstream protein
TGF-β1 activates the ROS-Nrf2 pathway, which was necessary for both Notch signaling activation and EMT development. Furthermore, Notch4 transcription was directly regulated by Nrf2. These results underscore a novel role for the ROS-Nrf2 pathway in TGF-β1-induced EMT through direct interaction ...
As Nrf2 regulates a major cellular defense mechanism, tight regulation is crucial to maintain cellular homeostasis. Activation of this pathway is important in preventing human diseases, such as cancer, neurodegenerative disease, cardiovascular diseases, ischemia, diabetes, pulmonary fibrosis, and ...
Both the shRNA of Nrf2 and the chemical inhibitor of HO-1 suppressed the induced radio-resistance, indicating the involvement of Nrf2 antioxidant pathway in this process. Further, we found 5cGy radiation stimulated autophagy process in A549. Inhibition of the autophagy process resulted in ...
2.2. The Tg(8xAORE:EGFP)ia201 Line Is Responsive to Nrf2 Pathway Modulators To verify whether the newly generated transgenic line is a bona fide Nrf2 pathway reporter, we performed several pharmacological tests based on the administration of well-known Nrf2 pathway agonists and antagonists. Toward...