Downregulation of the Nrf2/HO-1 signaling pathway significantly increased oxidative stress, neuroinflammation, immune dysregulation, oligodendrocyte loss, and demyelination associated with MS-like neurocomplications. The primary goal of this review is to clarify the downregulation of Nrf2/HO-1 signaling, ...
Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and... S Petri,S K?Rner,M Kiaei - 《...
Furthermore, the significance of this pathway in diabetes had been linked Nrf2 signaling activation When cells are exposed to a different range of environmental toxicants, mutagens, and potential carcinogens, they are prone to be attacked by various oxidative stress-related disturbances. Therefore, ...
Nitric Oxide (NO) is a versatile signaling molecule produced by various cell types and plays a pivotal role in inflammation and oxidative stress in skin tissue [52]. Being a free radical, NO can react with superoxide anions to form peroxynitrite, a potent oxidizing agent that inflicts damage o...
Melatonin and the Nrf2 signaling pathway Nrf2 is the principal regulator of antioxidant protection mechanisms (Shih2006). In the absence of oxidative stress, the transcription factor Nrf2, and Keap1 (Protein 1 associated with ECH (epichlorohydrin)) are bound in the cytoplasm (Fukutomi et al.2014...
f Schematic illustration of the role of USP25 and its inhibitor in regulating the KEAP1-NRF2 signaling pathway to oppose APAP-induced liver injury. Error bars denote SEM. Two-tailed student’s t tests analysis (c), non-parametric tests with blue colored (b). Source data are provided as a...
NF-κBIκBIKKTNF-αCellsignalingHonokiol, a small molecular weight lignan originally isolated from Magnolia officinalis, shows anti-angiogenic, anti-invasive ... Anfernee,Kai-Wing,Tse,... - 《Biochemical Pharmacology》 被引量: 134发表: 2005年 NF-κB and Nrf2 signaling pathways contribute to wogon...
Nrf2 is a crucial transcription factor that controls a critical anti-oxidative stress defense system and is implicated in skin homeostasis. Apigenin (API), a potent cancer chemopreventive agent, protects against skin carcinogenesis and elicits multiple molecular signaling pathways. However, the potential ...
2 signaling pathway Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathwayActivation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathwayCurcumin...
When NRF2 talks, who's listening? Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to c... N Wakabayashi,SL Slocum,JJ Skoko,... - 《Antioxid Redox Signal》 被引量: 580发表: 2010年 The ca...