Downregulation of the Nrf2/HO-1 signaling pathway significantly increased oxidative stress, neuroinflammation, immune dysregulation, oligodendrocyte loss, and demyelination associated with MS-like neurocomplications. The primary goal of this review is to clarify the downregulation of Nrf2/HO-1 signaling, ...
Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and... S Petri,S K?Rner,M Kiaei - 《...
Furthermore, the significance of this pathway in diabetes had been linked Nrf2 signaling activation When cells are exposed to a different range of environmental toxicants, mutagens, and potential carcinogens, they are prone to be attacked by various oxidative stress-related disturbances. Therefore, ...
f Schematic illustration of the role of USP25 and its inhibitor in regulating the KEAP1-NRF2 signaling pathway to oppose APAP-induced liver injury. Error bars denote SEM. Two-tailed student’s t tests analysis (c), non-parametric tests with blue colored (b). Source data are provided as a...
NF-κBIκBIKKTNF-αCellsignalingHonokiol, a small molecular weight lignan originally isolated from Magnolia officinalis, shows anti-angiogenic, anti-invasive ... Anfernee,Kai-Wing,Tse,... - 《Biochemical Pharmacology》 被引量: 134发表: 2005年 NF-κB and Nrf2 signaling pathways contribute to wogon...
These pathogenic events were found to be closely related to the suppression of the antioxidant signaling pathway, Nrf2 (nuclear-factor erythroid 2–related factor-2)/SIRT1 (sirtuin-1)/HO-1 (heme-oxygenase 1). On the other hand, OA significantly ameliorated TAA-induced injury in both organs....
There was evidence that curcumin scavenged free radicals by inducing the acti- vation of the nuclear factor erythroid-2-related factor-2 (Nrf2) signaling pathway (He et al., 2012). Research has shown that curcumin exerts anti-inflammatory effects by binding to pro-inflammatory molecules such as...
When NRF2 talks, who's listening? Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to c... N Wakabayashi,SL Slocum,JJ Skoko,... - 《Antioxid Redox Signal》 被引量: 580发表: 2010年 The ca...
Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide- stimulated mouse RAW 264.7 macrophages. Int Immunopharmacol 2015; 29: 770-778 [PMID: 26388191 DOI: 10.1016/j.intimp.2015.08.042]...
Mechanism study found that Nrf2/ARE signaling pathway was activated by MG-CH, whereas loss of hepatocytic Nrf2 abolished its anti-fibrotic effect significantly. Furthermore, it was demonstrated that MG-CH is a non-canonical NRF2 inducer, which promoted the autophagy activity and release the Nrf2...