Dissecting molecular cross-talk between Nrf2 and NF-kappaB response pathways. Biochem. Soc. Trans. 43, 621e626.Wardyn, J.D.; Ponsford, A.H.; Sanderson, C.M. Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways. Biochem. Soc. Trans. 2015, 43, 621-626. [CrossRef]...
Then, with the help of the cAMP-response element binding protein (CREB), transcription activators, etc., Nrf2-mediated transcription process is initiated to regulate the downstream gene expression; activate a series of antioxidant enzymes and phase II antioxidant enzymes, such as HO-1, NAD(P)H:...
One of the pathways that was significantly related to altered synaptic genes was Nrf2-mediated oxidative stress response. Nrf2 is a transcription factor that regulates the expression of genes that protect cells from various injuries via their anti-inflammatory effects. Nrf2 prevents lipopolysaccharide-indu...
mechanism of Nrf2 as the main regulator of antioxidant stress in SCI, and the influence of cross-talk between Nrf2 and related pathways that may be involved in the pathological regulation of SCI on oxidative stress, and summarized the drugs and other treatment methods based on Nrf2 pathway ...
These include sulforaphane, a substance found in cruciferous vegetables, which can activate Nrf2, a transcription factor that controls antioxidant and detoxification pathways and can induce apoptosis in cancer cells96. Overall, the use of nutraceuticals in cancer prevention and treatment is an exciting ...
indicating that mitochondrial damage contributes to the apoptosis of infected cells [25]. As shown in human primary neurons, HIV-1 gp120 and Tat proteins induce the mitochondrial fission process via DRP1 as a result of neural mitochondrial fragmentation and then activate mitophagy markers such as LC...
Progestin exerts inhibitory effects on EC cells by inducing G0/G1 cell cycle arrest through the regulation of multiple signaling pathways [25]. By disrupting the cell cycle progression, progestin can impede the uncontrolled proliferation of cancer cells. Moreover, progestin has the ability to induce...
DNA mutations can confer genes with the gain and loss of functions mutation. Some tumor suppressor genes become lethal on mutating and have been associated with highly aggressive cancers [237,238].BRCA2, NOTCH, RB2, KEAP1, NRF2were among the topmost mutated genes in metastatic BC cases. These...
MicroRNAs activate gene transcription epigenetically as an enhancer trigger. RNA Biol. 14, 1326–1334 (2016). Article PubMed PubMed Central Google Scholar Liu, X. et al. Regulation of microRNAs by epigenetics and their interplay involved in cancer. J. Exp. Clin. Cancer Res. 32, 96 (2013...
[15,16,17,18,19,20,21]. However, due to the aggressive nature of prostate cancer cells, they acquire resistance to different therapies [22,23]. They can activate tumor-promoting signaling pathways to induce chemoresistance, radio-resistance, ADT resistance and immune-resistance [24,25,26,27,...