Nrf2/HO-1CytoglobinBackground Purpose: Valproate (VPA) is an antiepileptic drug widely used to treat various psychiatric and neurological disorders. Although its use is generally considered safe, chronic admini
Valproate Indole-3-acetic acid Chenodeoxycholic acid Nrf2/HO-1 Cytoglobin List of Abbreviations: Abbrev.DefinitionAbbrev.Definition VPA Valproate Nrf2 Nuclear factor erythroid 2-related factor IAA Indole-3-acetic acid ROS Reactive oxygen species CDCA Chenodeoxycholic acid IACUC Institutional Animal Care and...
At the molecular level, DIA induced significant upregulation in Nrf2, HO-1, PPAR-纬, and cytoglobin protein expression. The present results proved that DIA, in a dose-dependent manner, exhibited notable amelioration of testicular toxicity induced by MTX through augmentation of anti-inflammatory and...
In conclusion, NFX treatment prevents INDO nephrotoxicity by regulating Nrf2/HO-1, cytoglobin, NADPH-oxidase, NF-魏B, and JAK-1/STAT3 signals.doi:10.1007/s00210-023-02851-5Emad H. M.,HassaneinDepartment of Pharmacology & ToxicologyMustafa Ahmed,Abdel-Reheim...
Mechanistically, rats administered Cis only exhibited a significant decrease in NRF2 and cytoglobin expressions as well as the CREB, SIRT1, FOXO-3, and PPAR-γ genes. Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB...
Mechanistically, rats administered Cis only exhibited a significant decrease in NRF2 and cytoglobin expressions as well as the CREB, SIRT1, FOXO-3, and PPAR-γ genes. Treatment with UMB significantly upregulated NRF2 and cytoglobin proteins, as well as effectively increased the expression of CREB...
MP79-10 SILDENAFIL ACTIVATES NRF2 DEPENDENT ANTI-OXIDANT GENES AND ANTI-APOPTOTIC BCL-2 GENE AND INHIBITS PRO-INFLAMMATORY CYTOKINES GENES IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY - The Journal of Urologydoi:10.1016/j.juro.2015.02.2867Zahran...
ChIP-qPCR-WB with specific probes was used to examine Bmal1-Nrf2 enrichment at E-box/ARE of Prdx6 gene. Wildtype/mutants biotinylated oligos mutated at E-box (CA(T)CGT(A)G) or ARE (T(G)G(T)AnnnnnGC) was incubated with nuclear extract of LECs, the complex was pulled out with ...