Amaral PP, Mattick JS (2008) Noncoding RNA in development . Mamm Genome 19 : 454–492Amaral PP, Mattick JS. Noncoding RNA in development. Mamm Genome. 2008; 19 (7-8):454–92. doi: 10.1007/s00335-008-9136-7. [ Cross Ref ]...
doi:10.1016/j.gendis.2023.02.008\nLong noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentia ... 1\nIntroduction 2\nCritical roles of H19 in embryogenesis and development 2\nMolecular mechanisms underlying H19 functions 3\n...
which appeared in 82 and 63 iterations out of the 100 iterations performed, respectively (Fig.2A). LEF1-AS1 is a lncRNA of 3,360 nucleotides transcribed from the lymphoid enhancer binding factor 1 (LEF1) locus located on chromosome 4. In the merged European cohorts (discovery cohort,n =...
48, 49 Most lncRNAs are transcribed by RNA polymerase II enzymes that lack open-reading frames and are expressed in specific tissues and/or during specific developmental stages, demonstrating that the genes encoding these molecules are strictly regulated with respect to tissue development. Previous ...
Nasopharyngeal carcinoma (NPC) is the most common type of malignancy of the neck and head in Southeast Asia and North Africa. Long noncoding RNA (LncRNA) Differentiation antagonizing nonprotein coding RNA (DANCR) has been reported to exert oncogenic functions in various malignant tumors. However,...
7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-,...
The years following publication of the draft human genome sequence brought about a dramatic change in our understanding of the organization and expression of genetic information. Discoveries of new classes of RNA without protein coding potential and larg
Objective: Recently, the role of long noncoding RNA (lncRNAs) in tumor progression has attracted much attention. The aim of this study was to investigate the role of lncRNA SNHG16 in the development of Wilms' tumor, and to explore the underlying mechanism. Patients and methods: Real Time-...
, tumour-initiating transposon screens in mouse31 and function-altering germline cancer variants32. LncRNA genes also tend to be highly mutated in tumour DNA2,33,34. For example, the NEAT1 lncRNA, which is a structural component of subnuclear paraspeckle bodies, has been noted for its high...
000 human lncRNA transcripts from almost 100,000 genes. While their biological significance and mechanisms of action are still being elucidated, they have been implicated in a wide range of biological functions including development and disease progression. Most lncRNAs are transcribed by RNA polymerase...