Noncoding RNA in development. Mamm Genome. 2008;19(7-8):454-492; doi: 10.1007/ s00335-008-9136-7.Amaral PP, Mattick JS. Noncoding RNA in development. Mamm Genome 2008; 19:454-492.Amaral PP, Mattick JS. Noncoding
However, analyses of transcriptional bursting to date have focused on protein-coding genes and it is unknown whether the low expression of lncRNAs is mediated by lowered burst sizes (fewer RNA molecules per cell) or burst frequencies (expression in fewer cells). Moreover, comprehensive analyses of...
As a first step to exploring this possibility, RNA-seq was used to generate transcriptomic profiles of small noncoding RNAs in embryos developing along the two alternative trajectories. We find distinct profiles of mature sequences belonging to the miR-10 family expressed in increasing abundance ...
Nasopharyngeal carcinoma (NPC) is the most common type of malignancy of the neck and head in Southeast Asia and North Africa. Long noncoding RNA (LncRNA) Differentiation antagonizing nonprotein coding RNA (DANCR) has been reported to exert oncogenic functions in various malignant tumors. However,...
7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-,...
Long noncoding RNADiagnosisPrognosisHepatocellular carcinoma (HCC) is a complex disease with multiple underlying pathogenic mechanisms caused by a variety of etiologic factors. Emerging evidence showed that long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides (nt), play important roles...
The years following publication of the draft human genome sequence brought about a dramatic change in our understanding of the organization and expression of genetic information. Discoveries of new classes of RNA without protein coding potential and larg
is still a paucity of studies addressing the role of the lncRNA in plants, more importantly peanut. To date, genome-wide analyses of lncRNAs have been carried out in several plants, but the numbers and characteristics of lncRNAs involved in seed development have not yet been explored in ...
, tumour-initiating transposon screens in mouse31 and function-altering germline cancer variants32. LncRNA genes also tend to be highly mutated in tumour DNA2,33,34. For example, the NEAT1 lncRNA, which is a structural component of subnuclear paraspeckle bodies, has been noted for its high...
48, 49 Most lncRNAs are transcribed by RNA polymerase II enzymes that lack open-reading frames and are expressed in specific tissues and/or during specific developmental stages, demonstrating that the genes encoding these molecules are strictly regulated with respect to tissue development. Previous ...