NON-coding RNABONE resorptionUBIQUITIN ligasesLABORATORY miceOSTEOPOROSISLong noncoding RNAs are widely implicated in diverse disease processes. Nonetheless, their regulatory roles in bone resorption are undefined. Here, we identify lncRNA Nron as a critical suppressor of bone resorption. We demonstrate ...
L. RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells. eLife 3, e02112 (2014). Article PubMed PubMed Central Google Scholar Zhang, Y., Yang, L. & Chen, L. L. Life without a tail: new formats of long noncoding RNAs. Int. J. Biochem. Cell Biol. 54, 338–...
Long non-coding RNA Long non-codingRNAs(lncRNAs; >200 nt) are the most abundant class of RNAs. Compared to the approximately 20,000 protein-coding genes in humans (Carninci & Hayashizaki, 2007; Jia et al., 2010; Ravasi, 2006), current annotations indicate that there are >16,000 lncRNAs...
LongNoncoding RNAsGuide the Epigenetic Machinery and Interfere with OtherNoncoding RNAFunctions to Regulate Gene Expression 106 4.1 Paradigms of Long NoncodingRNAFunction in the Regulation of Gene Expression 106 4.1.1 Long NoncodingRNAsas Guides for the Epigenetic Machinery 108 ...
Long noncoding RNAs (lncRNAs) are non-protein-coding RNA transcripts that exert a key role in many cellular processes and have potential toward addressing disease etiology. Here, we review existing noncoding RNA classes and then describe a variety of mechanisms and functions by which lncRNAs ...
LncRNA (Long non-coding RNA) is a class of non-coding RNA molecules with lengths exceeding 200 nucleotides and lacking protein-coding functions.
[99]. Among these putative mitochondrial DNA-encoded lncRNAs, the most significant was called long intergenic noncoding RNA predicting CARdiac remodeling (LIPCAR).LIPCAR, a chimeric lncRNA, contains 781 nucleotides. Mapping the completeLIPCARsequence to the human mitochondrial genome showed that the 5...
Long noncoding RNA in genome regulation:Prospects andmechanisms. Hung T,Chang HY. RNA Biol . 2010Hung T, Chang HY: Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 2010;7:582-585.Hung T and Chang HY: Long noncoding RNA in genome regu- lation: prospects and ...
lncRNA【Long Noncoding RNA】即长非编码RNA。作为不编码蛋白质的DNA,这部分DNA曾经一度被人们认为是“垃圾DNA”,它的转录产物被称为“转录噪声”。经研究发现这其中有些RNA虽然不直接参与基因编码和蛋白质合成,但是在基因转录后【调控】、【剪切】和【修饰】具有十分重要的功能。【那么判断一个lncRNA是否是转录...
(C)LncRNAsequencesconveyfunctionsthroughbindingtoDNAorprotein.(D)NoncodingRNAsregulatetranscriptionincisindirectly,withoutbindingtoDNA.(E)LncRNArealizeditsfunctionbyformingaribonucleoproteincomplex.(F)Oligomerizationofanactivatorprotein.LncRNAsasTranscriptionalregulator (G)LncRNAsregulatetranscriptionindirectlybycontrolling...