Long non-coding RNAsRNA metabolismA diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus...
Yao, RW., Wang, Y. & Chen, LL. Cellular functions of long noncoding RNAs.Nat Cell Biol21, 542–551 (2019). https://doi.org/10.1038/s41556-019-0311-8 Download citation Received12 August 2018 Accepted11 March 2019 Published02 May 2019 ...
Yao RW, Wang Y, Chen LL (2019) Cellular functions of long noncoding RNAs. Nat Cell Biol 21(5):542–551 ArticleCASPubMedGoogle Scholar Cheng J, Meng J, Zhu L, Peng Y (2020) Exosomal noncoding RNAs in glioma: biological functions and potential clinical applications. Mol Cancer 19(1):1...
2. Long non-coding RNAs (lncRNAs) The incredible exertion prompted the amazing revelation that in the human genome 70–90% of the DNA is deciphered yet just 2% encodes for proteins [8]. In the last few years, with the improved sequencing advancements, it is surely certain that the human...
Since decades it has been known that non-protein-coding RNAs have important cellular functions. Deep sequencing recently facilitated the discovery of thousands of novel transcripts, now classified as long noncoding RNAs (lncRNAs), in many vertebrate and invertebrate species. LncRNAs are involved in a...
Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy The Journal of Pharmacology and Experimental Therapeutics Volume 365, Issue 3, June 2018, Pages 494-506 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor acad...
Head and neck squamous carcinoma (HNSC) is the most prevalent malignancy of the head and neck regions. Long noncoding RNAs (lncRNAs) are vital in tumorigenesis regulation. However, the role of lncRNA...
Changes in the structure and function of shelterin complex proteins can promote tumorigenesis and cancer progression. Understanding shelterin complex biology suggests that targeting shelterin proteins could be a novel strategy for cancer therapy. The messenger RNA (mRNA)-microRNA (miRNA)-long noncoding ...
Our present study may help to lead a better understanding of the pathogenesis of cervical cancer (CC), provide a novel possible tumor biomarker, and probe the feasibility of long noncoding RNA-direct...
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure and turnover and thereby have unique cellular functions and potential biomedical applications. In this Review, I discuss recent ...