作为DNA损伤的直接靶点之一,位于CDKN1A基因上游的lncRNA称为lincRNA-p21,在典型的p53通路中起转录抑制作用,并在触发细胞凋亡中起作用。p53通过直接诱导lincRNA-p21的表达来调节lincRNA-p21的表达,而基因间lincRNA-p21的减少增加了大量p53抑制转录本的表达。此外,lincRNA-p21通过与异质性核糖核蛋白K(hnRNP-K)的定位结...
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. Here we discuss the emerging archetypes of molecular functions that lncRNAs execute—as signals, decoys, guides, and scaffolds. For each archetype, examples from several disparate ...
New Insights into the Molecular Mechanisms of Long Non-coding RNAs in Cancer Biologyantagomircancerdruglocked nucleic acid (LNA)microRNA (miRNA)mimicsspongetherapyvirusA very expensive research was carried out in the last decades to understand the molecular physiology of cancer cells, and despite of...
Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor prognosis of EC. In addition, the underlying molecular mechanisms of EC development h...
An increasing number of long noncoding RNAs (lncRNAs) have experimentally confirmed functions, yet little is known about their transcriptional dynamics and it is challenging to determine their regulatory effects. Here, we used allele-sensitive single-cell RNA sequencing to demonstrate that, compared to...
Fig. 1: Biogenesis and cellular fates of long non-coding RNAs. a| Biogenesis of long non-coding RNAs (lncRNAs). Unlike mRNAs, many RNA polymerase II (Pol II)-transcribed lncRNAs are inefficiently processed4,5,113and are retained in the nucleus6,10,12,13,16(mechanisms of lncRNA nuclear ...
根 据其长度的大小,调节性非编码 RNAs 可被简单的划分为两大类,即小分子非编 码 RNAs (small noncoding RNAs )和大分子非编码RNAs (long noncoding RNAs, lncRNAs )。目前,对调节性非编码 RNAs 研究较多的是一些小分子非编码 RNAs , 包括 miRNA 、siRNA 和 piRNA 等[7-8] 。小分子非编码 RNAs 具有...
and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that...
Molecular Mechanisms of Long Noncoding RNAs 2011, Molecular Cell Show abstract Unique features of long non-coding RNA biogenesis and function 2016, Nature Reviews Genetics Long non-coding RNAs: New players in cell differentiation and development 2014, Nature Reviews Genetics Long noncoding RNAs: Past...
Schematic mechanisms of lncRNA function in reproductive system cancers Full size image MALAT1 Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), also known as NEAT2 (noncoding nuclear-enriched abundant transcript 2), is an 8000 nt-long lncRNA located in chr11q13.1. It is involved ...