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Long noncoding RNA in genome regulation:Prospects andmechanisms. Hung T,Chang HY. RNA Biol . 2010Hung T, Chang HY: Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 2010, 7:582-585.Hung T and Chang HY: Long noncoding RNA in genome regulation: Prospects and ...
Essential long noncoding RNAs are identified using Cas9 targeting of splice sites. The functions of many long noncoding RNAs (lncRNAs) in the human genome remain unknown owing to the lack of scalable loss-of-function screening tools. We previously used p
Long non-coding RNAs are identified using a high-throughput paired-guide RNA genomic deletion screen. CRISPR–Cas9 screens have been widely adopted to analyze coding-gene functions, but high-throughput screening of non-coding elements using this method i
Chang Genome regulation by long noncoding RNAs Annu Rev Biochem, 81 (2012), pp. 145-166 CrossrefView in ScopusGoogle Scholar 3 R.A. Boon, N. Jaé, L. Holdt, et al. Long noncoding RNAs: from clinical genetics to therapeutic targets? J Am Coll Cardiol, 67 (10) (2016), pp. 1214...
Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2012;81:145–66. Article CAS PubMed Google Scholar Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific ...
China Abstract LongnoncodingRNAs(lncRNAs)havecrucialrolesincancerbiology.Weperformedagenome-wideanalysisoflncRNA expressioninhepatoblastomatissuestoidentifynoveltargetsforfurtherstudyofhepatoblastoma.Hepatoblastomaand normallivertissuesampleswereobtainedfromhepatoblastomapatients.Thegenome-wideanalysisoflncRNAexpression in...
Long noncoding (lncRNAs) are a functional and structural diverse class of cellular transcripts that comprise the largest fraction of the transcriptome. However, detailed functional analysis lags behind their rapid discovery. This might be partially due to the lack of loss-of-function approaches that ...
Magistri M, Faghihi MA, St Laurent G 3rd, Wahlestedt C. Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends Genet. 2012;28(8):389–96. Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, ...
An increasing amount of evidence suggests that long intergenic noncoding RNAs (lincRNAs) may play diverse roles in many cellular processes. However, little is known about lincRNAs in marine invertebrates. Here, we presented the first identification and characterization of lincRNAs in the Pacific ...