lncRNA【Long Noncoding RNA】即长非编码RNA。作为不编码蛋白质的DNA,这部分DNA曾经一度被人们认为是“垃圾DNA”,它的转录产物被称为“转录噪声”。经研究发现这其中有些RNA虽然不直接参与基因编码和蛋白质合成,但是在基因转录后【调控】、【剪切】和【修饰】具有十分重要的功能。【那么判断一个lncRNA是否是转录...
Long Noncoding RNAs (LncRNAs) are emerging players in a variety of cellular and physiological processes. Their mutations and aberrant expressions are associated with a variety of human diseases, including cancer, cardiovascular, neurological, immunological, and heritable disease. This chapter focuses on ...
lncRNA参与多种生物学过程的调控,在多种生命活动中发挥重要作用,该领域的关注度也日益增高,已成为继信使RNA(mRNA)、小RNA(microRNA、siRNA等)之后功能基因组学非常火热的研究领域。 服务要求 1.提供待测基因序列或登录号。 2.提供新鲜或保存完好的细胞(至少5×10的6次方)、组织(至少50mg)、血液(300μl)等样本...
例句 释义: 全部 更多例句筛选 1. Long Noncoding RNA HOTAIR Regulates Polycomb -Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers . 在结直肠癌中长非编码RNAHOTAIR调节多梳依赖的染色质修饰并且与疾病较差的预后相关。 blog.sina.com.cn隐私...
我们鉴定了外泌体长非编码RNA(lncRNA),称为淋巴结转移相关的转录子2(LNMAT2),在体外刺激了HLEC管的形成和迁移,并在体内增强了肿瘤的淋巴管生成和淋巴结转移。在机制上,LNMAT2通过与异质核糖核蛋白A2B1(HRNPA2B1)直接相互作用,将LNMAT2负载到BCa细胞分泌的外泌体上。随后,外泌体LNMAT2被HLECs内化,表观...
7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-,...
的从lncRNA出发预测靶基因不同,反向long noncoding RNA(lncRNA)靶基因预测是从感兴趣的已知基因开始(例如p53,COX-2等与肿瘤等密切相关的基因,这些基因可以来自芯片分析结果、NLP结果或客户给定的任何基因列表),利用我们的long noncoding RNA(lncRNA)数据库和靶基因预测软件pipeline,找到潜在的调节这些基因的lncRNA。
Chang, Long noncoding RNA in genome regulation, RNA Biol. 7 (5) (2014) 582-585.Hung T, Chang HY: Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 2010, 7: 582–585.Long noncoding RNA in genome regulation[J] . Tiffany Hung,Howard Y. Chang. RNA; ...
With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-co
长链非编码RNA--lnc121610参与子宫内膜异位症内膜蜕膜化机制研究 目的子宫内膜异位症(EMs)是一种雌激素依赖性女性疾病,目前认为,是子宫内膜腺体细胞和基质细胞异位至宫腔之外的部位而引发的,以不孕和疼痛为典型症状.蜕膜化是子宫内膜... 杨琳 - 厦门大学 被引量: 0 Hepatitis B virus X protein (HBx)-related ...