lncRNA【Long Noncoding RNA】即长非编码RNA。作为不编码蛋白质的DNA,这部分DNA曾经一度被人们认为是“垃圾DNA”,它的转录产物被称为“转录噪声”。经研究发现这其中有些RNA虽然不直接参与基因编码和蛋白质合成,但是在基因转录后【调控】、【剪切】和【修饰】具有十分重要的功能。【那么判断一个lncRNA是否是转录...
RNA sequencingdorsal root ganglionepigeneticsneuropathic painspinal cordCurrent treatments for neuropathic pain are limited at least in part due to the incomplete understanding of its underlying mechanisms. Recent evidence reveals the dysregulated expression of long non-coding RNAs (lncRNAs) in the damaged...
While lncRNAs have the capacity to regulateKRASexpression, abnormal levels of KRAS, one of the mediators of many cellular signaling pathways, reciprocally cause diverse molecular alterations, such as dysregulation of lncRNA expression.KRASamplification has been shown to be a secondary means of KRAS act...
Long noncoding RNA in genome regulation[J] . Tiffany Hung,Howard Y. Chang.RNA Biology . 2010 (5)Hung T and Chang HY: Long noncoding RNA in genome regu- lation: prospects and mechanisms. RNA Biol 7: 582‑585, 2010.Hung T, Chang HY: Long noncoding RNA in genome regulation: ...
7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-,...
Integrative driver lncRNA discovery with ExInAtor2 Driver genes can be identified by signals of positive selection acting on their somatic mutations. The two principal signals are mutational burden (MB), an elevated mutation rate, and functional impact (FI), the degree to which mutations are predi...
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological
lncRNA参与多种生物学过程的调控,在多种生命活动中发挥重要作用,该领域的关注度也日益增高,已成为继信使RNA(mRNA)、小RNA(microRNA、siRNA等)之后功能基因组学非常火热的研究领域。 服务要求 1.提供待测基因序列或登录号。 2.提供新鲜或保存完好的细胞(至少5×10的6次方)、组织(至少50mg)、血液(300μl)等样本...
长非编码RNA(Long noncoding RNAs,lncRNA)是一类新型调控分子,近期研究发现其在从胚胎发育到肿瘤发生等多种生理病理过程中发挥核心调控作用。因此,随着越来越多的长非编码RNA被鉴定,一批计算工具应运而生,为生物学家预测lncRNA的GO功能和调控网络、亚细胞定位,乃至lncRNA-RNA、lncRNA-蛋白相互作用等提供了重要的工具...
定义 长链非编码RNA(long noncoding RNA, lncRNA) ◆ 长度在200-100000 nt之间的RNA分子 ◆不编码蛋白 ◆ lncRNA参与细胞内多种过程调控 ◆种类、数量、功能都不明确 ◆Antisense lncRNA (反义长非编码RNA) ◆Intronic transcript (内含子非编码RNA) ◆...