RNA-mediated symmetry breaking enables singular olfactory receptor choice Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a...
LncRNA (Long non-coding RNA) is a class of non-coding RNA molecules with lengths exceeding 200 nucleotides and lacking protein-coding functions.
7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-,...
Long noncoding RNAs (lncRNAs) are a subset of RNAs that are longer than 200 nt, have mRNA structure, and are usually polyadenylated but rarely encode proteins17. Increasing studies have reported that lncRNAs play multiple roles in the regulation of development and differentiation. Recent studies...
Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. Hum Mol Genet 2011 ; 20:705 - 18; http://dx.doi.org/ 10.1093/hmg/ddq516 ; PMID: 21118898Vallot, C. & Rougeulle, C. Long non-coding RNAs and human X-chromosome ...
Many of them are long noncoding RNA (lncRNA), which form 80% of the human noncoding transcriptome [1,2]. While some of the noncoding RNAs may be transcriptional noise or high throughput sequencing artifacts [3,4], others are involved in the regulation of various biological pathways. They...
First, evidence from a study of noncoding 5S rRNA and tRNA targeted to mitochondria suggests an RNA import pathway dependent on the protein import system [67,68,69,70]. Second, the RBP of PNPASE, localized in the mitochondrial intermembrane space, facilitates the transfer of a hybrid RNA ...
Chapter 4 Long Non-coding RNA Monika Gullerova Introduction Rapid developments in sequencing technologies during past decade revealed that protein coding genes represent only 2 % of the human genome [1]. This came across as a surprise considering that genomes of the other organisms (from yeast to...
There are several types of non-coding RNA molecules of known functions. For instance, ribosomal RNAs (rRNA) in protein translation, small nuclear RNA (snRNA) in splicing of immature mRNA, microRNA (miRNA), and small interfering RNA (siRNA) in gene silencing. The length of the lncRNAs ranges...
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we report and characterize a lncRNA, termed Brain...