However, we are only beginning to understand the nature and extent of the involvement of non-coding RNAs (ncRNAs) in disease. Other ncRNAs, such as PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), transcribed ultraconserved regions (T-UCRs) and large intergenic non-coding RNAs...
The non-protein-coding genome is gaining prominence in biology and medicine. The most well-studied non-coding RNAs (ncRNAs) are microRNAs (miRNAs), but many other types of ncRNAs also have major roles in cellular homeostasis and disease. These additional ncRNAs include PIWI-interacting RNAs (piRN...
Non-coding RNAs (ncRNAs) are, arguably, the enigma of the RNA transcriptome. Even though there are more annotated ncRNAs (25,967) compared to mRNAs (19,827), we know far less about each of the genes that produce ncRNA, especially in terms of their regulation, molecular functions, and int...
Non-coding RNAS in human diseases The relevance of the non-coding genome to human disease has mainly been studied in the context of the widespread disruption of microRNA (miRNA) expression ... M Esteller - 《Nature Reviews Genetics》 被引量: 3439发表: 2011年 Long non-coding RNAs: A new ...
Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861–74. Google Scholar Calore F, Lovat F, Garofalo M. Non-coding RNAs and Cancer. Int J Mol Sci. 2013;14(8):17085–110. Yu B, et al. The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans ...
Noncoding RNAs in KRAS-driven cancers The noncoding transcriptome consists of a variety of different RNA types, such as transfer RNA (tRNAs), ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), circular RNAs (circRNAs), miRNAs, and lncRNAs. Other than miRNAs...
Targetable long non-coding RNAs in cancer treatments Liang Chen, Emmanuel Enoch Dzakah, Ge Shan 1 April 2018 Pages 119-124 select article tRNA-derived small non-coding RNAs in human disease Mini reviewAbstract only tRNA-derived small non-coding RNAs in human disease ...
Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … Vi...
Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861–74. CAS PubMed Google Scholar Liang J, Liu X, Xue H, Qiu B, Wei B, Sun K. MicroRNA-103a inhibits gastric cancer cell proliferation, migration and invasion by targeting c-Myb. Cell Prolif. 2015;48(1):78–85. ...
Non-coding RNAsPatternAlthough non-coding RNAs (ncRNAs) are commonly considered modulators in human disease, revealing the methylation pattern of ncRNA is still a challenging task. In this chapter, we (1) introduced a strategy of constructing DNA methylation profiles for ncRNAs by reannotating data...