In the last few years, ncRNAs have received a lot of research attention, especially microRNAs, long noncoding RNAs, and circular RNAs, which have a well-known association with the development of human disease and are closely related to the biological phenotypic changes caused by IR. With recent...
This cap is uniquely found in small nuclear RNAs (snRNA) with a 5′ trimethylguanosine caps and in the long non-coding RNA (lncRNA) as 5′ monomethyl phosphate cap. In bacteria and some organisms, the mRNA is capped with NAD+, NADH, or 3′ dephospho-coenzyme A. In all organisms, mR...
MicroRNAs (miRNAs) are a highly abundant class of small (~22 nt), endogenous and evolutionarily con- served single-stranded non-coding RNAs that regulate the gene expression normally at post-transcriptional level by base pairing with their target mRNAs at 3′ untranslated regions (UTRs), ...
Non-humans are everywhere these days. Sure, you’ve seen the much-deserved hype about how AI-powered tools like ChatGPT are going to change everything. But there are plenty of more mundane...
of cpMSCs, CSCs/CPCs, and CDCs, and pluripotent stem cells such as ESCs and iPSCs. Next-generation therapies for cardiac repair are directed toward cell enhancement (e.g., biomaterials, 3D cell constructs, cytokines, miRNAs) and cell-free concepts (e.g., growth factors, non-coding RNAs,...
Tissue-specific regulation of mRNA function is performed post-transcriptionally by small non-coding RNAs, specifically microRNAs (miRNA). Human cancer cells exhibit substantial dysregulation of miRNA expression, stemming from various factors including epigenetic alterations, karyotype irregularities, and flaws ...
Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cel
Purified RNAs from these tissues were submitted for Illumina 100 base pair, paired-end RNA sequencing. Reads were assembled with Trinity software, and transcript abundance was estimated with RSEM (RNA sequencing by expectation-maximization). To identify marker genes restricted to the mesopallium and ...
In addition, miRNAs and long noncoding RNAs were not considered in this GCN analysis, both of which have been shown to modulate plant pathogen resistance50,51. Nevertheless, our estimates represent a genome-wide assessment of the number of protein-coding genes likely taking part in IM or HR ...
et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458, 223–227 (2009). Article CAS PubMed Central PubMed Google Scholar Marques, A.C. & Ponting, C.P. Catalogues of mammalian long noncoding RNAs: modest conservation and ...