In the last few years, ncRNAs have received a lot of research attention, especially microRNAs, long noncoding RNAs, and circular RNAs, which have a well-known association with the development of human disease and are closely related to the biological phenotypic changes caused by IR. With recent...
(siRNAs) bind to complementary sequences on mRNA and inhibit protein synthesis either by blocking the access of the translation machinery to the mRNA or by degrading the mRNA itself. Long non-coding RNAs interact with and recruit enzymes that chemically modify DNA and histones — proteins that ...
This cap is uniquely found in small nuclear RNAs (snRNA) with a 5′ trimethylguanosine caps and in the long non-coding RNA (lncRNA) as 5′ monomethyl phosphate cap. In bacteria and some organisms, the mRNA is capped with NAD+, NADH, or 3′ dephospho-coenzyme A. In all organisms, mR...
Small non-coding RNAs (ncRNAs) are important regulators of gene expression in eukaryotes. Previously, only microRNAs (miRNAs) and piRNAs have been identified in the silkworm, Bombyx mori. Furthermore, only ncRNAs (50-500nt) of intermediate size have been systematically identified in the silkworm....
Multiplexed nucleotide-level perturbations or randomizations will be instrumental in calibrating GET for precise prediction of the functional impact of non-coding genetic variants. Determining the effects of non-coding variants in modulation of gene expression and disease susceptibility remains an important ...
Long-stranded noncoding RNAs (lncRNAs) are a group of RNAs that are longer than 200 nucleotides and without protein-coding ability. Current researches indicated that the dysregulated expression of lncRNAs not only impaired normal cell growth and development, but also interfered with the cell cycle ...
Identifying pathogenic variants from the vast majority of nucleotide variation remains a challenge. We present a method named Multimodal Annotation Generated Pathogenic Impact Evaluator (MAGPIE) that predicts the pathogenicity of multi-type variants. MAG
et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458, 223–227 (2009). Article CAS PubMed Central PubMed Google Scholar Marques, A.C. & Ponting, C.P. Catalogues of mammalian long noncoding RNAs: modest conservation and ...
MicroRNAs (miRNAs) are a highly abundant class of small (~22 nt), endogenous and evolutionarily con- served single-stranded non-coding RNAs that regulate the gene expression normally at post-transcriptional level by base pairing with their target mRNAs at 3′ untranslated regions (UTRs), ...
Another set of spliceosomes termed ‘minor spliceosomes’ are also found in eukaryotic cells which have less abundant RNAs and are involved in the splicing of a rare class of pre-mRNA introns. RNA Splicing Process/ Mechanism The process of RNA splicing begins with the binding of the ribonucleop...