They affect the structure of chromatin, activity of transcription factors, posttranscriptional modifications and the stabilty of RNA. In mammals, noncoding transcripts have been linked to regulation of many cellular mechanisms and their proper expression is crucial for normal development, growth ...
Chapter 5 – Noncoding RNA Regulation of Health and DiseaseThe advent of next-generation sequencing (NSG) techniques revealed the existence of a large portion of transcribed noncoding elements in our genome. Often referred to as the "dark matter" of the genome, these noncoding RNAs (...
In summary, this work demonstrates the utility of driver analysis for mapping cancer-promoting lncRNAs, and provides experimental evidence that somatic mutations can act through lncRNAs to enhance pathological cancer cell fitness.Similar content being viewed by others Cancer LncRNA Census reveals evidence...
Targeting Noncoding RNAs in Disease: Challenges and Opportunities Many RNA species have been identified as important players in the development of chronic diseases, including cancer. Over the past decade, numerous studies have highlighted how regulatory RNAs such as microRNAs (miRNAs) and long noncod...
LncRNAs are RNAs longer than 200 nucleotides that are not translated into proteins. They are transcribed by RNA polymerase I (Pol I), Pol II, and Pol III, and some of them are from processed introns [29]. The number of lncRNA is numerous. More than 100,000 lncRNAs have been found in...
Parkinson's diseasesynapsesLong noncoding RNAs (lncRNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lncRNAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and ...
Targeting noncoding RNAs in disease Many RNA species have been identified as important players in the development of chronic diseases, including cancer. Over the past decade, numerous studies have highlighted how regulatory RNAs such as microRNAs (miRNAs) and long noncodin......
Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol. Rev. 87:799-823. http://dx.doi.org/10.1152/physrev.00036.2006Mehler MF, Mattick JS: Noncoding RNAs and RNA editing ... MF Mehler,S Mattick 被引量: 6发表: 2013年 A Systemat...
- 《Cell Death & Disease》 被引量: 145发表: 0年 MUNC, a Long Noncoding RNA That Facilitates the Function of MyoD in Skeletal Myogenesis An in silico screen for myogenic long noncoding RNAs (lncRNAs) revealed nine lncRNAs that are upregulated more than 10-fold in myotubes versus levels in...
MicroRNA Long noncoding RNA Aging Cardiovascular disease 1. Introduction 1.1. Gene regulation by ncRNAs The adaptation of mammalian cells to external and internal signals requires precise transcriptional and post-transcriptional modulation of gene expression patterns. Transcription is controlled mainly through...