In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Abstract Thousands of unique non-coding RNA (ncRNA...
Non-coding RNA networks in cancer 来自 国家科技图书文献中心 喜欢 0 阅读量: 473 作者:E Anastasiadou,LS Jacob,FJ Slack 摘要: Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional ...
Cancer development and progression include many cellular processes, among which cellular signaling networks play crucial roles. The hallmarks of cancer cells are gained through the deregulation of these signaling pathways, which result in the evasion of apoptosis, invasion, angiogenesis, metastasis, and ...
10,11]. The ncRNAs have cell type, tissue and cancer specificity, thus RNA profiling has become a mean to identify useful biomarkers of tumor development, progression and metastasis. Although miRNAs represent the most widely investigated ncRNAs, lncRNAs are emerging as cancer key regulators [7,12]...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
PDAC cells via sEVs induces a more aggressive phenotype, as lncRNA-Sox2ot acts as a sponge to members of the miRNA-200 family, a potent suppressor of EMT [53,54]. Inhibition of miRNA-200 induces transcription factor Sox2, which (1) promotes EMT and cancer stemness in vitro as assessed...
研究结果以“Systematic Identification of Non-coding pharmacogenomic landscape in cancer”为题发表在《Nature Communications》杂志上。 LncRNA是一类长度超过200个核苷酸的ncRNA,少部分lncRNA在肿瘤细胞生长、迁移及耐药发生中的关键调控作用已被多次报道1-7,但人们对于大部分lncRNA在肿瘤细胞中的调控作用仍缺少系统的认...
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct...
Oncogene-induced regulation of microRNA expression: Implications for cancer initiation, progression and therapy Athanasios R. Paliouras, Tiziana Monteverde, Michela Garofalo 1 May 2018 Pages 152-160 select article Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma ...
With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-coding signaling pathways underlie various biologi...