LONG NON-CODING RNA IN CANCERThere are provided polynucleotides that is able to bind to and inhibit the long non coding RNA transcript SCAT7. These polynucleotides can be used for the treatment of cancer. Expression analysis of SCAT7 can be used for diagnosis of cancer.Chandrasekhar Kanduri...
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs (ncRNAs) with a minimum length of 200 nucleotides, which have been well studied in the context of RNA-based therapeutics [13,14]. Although only a small fraction of known lncRNAs have been functionally characterized, there is growing...
Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues Rahaba Marima,Afra Basera,Thabiso Miya,... - Non-coding RNA Re... - 2024 - 被引量: 0 The Role of Sex-specific Long Non-coding RNAs in Cancer Preve...
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct...
Keywords:long non-coding RNA,cancer,oncogenic lncRNA,tumor suppressor lncRNA Full-TextCite this paperAdd to My Lib Abstract: Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional,...
Long non-coding RNA (lncRNA) comprises a group of single-stranded RNA with lengths longer than 200 bp. LncRNAs are aberrantly expressed and play a variety of roles involving multiple cellular processes in cancer. Histocompatibility leukocyte antigen complex P5 (HCP5), initially reported in 1993, ...
The invention described in the application relates to a long non-coding RNA expressed in cancer. The invention thus provides methods and compositions for evaluating levels of the long non-coding RNA to assess the aggressiveness of a cancer and for modulating levels of the long non-coding RNA....
Long noncoding RNA in genome regulation: prospects and mechanisms RNA Biol., 7 (5) (2010), pp. 582-585 CrossrefView in ScopusGoogle Scholar [27] P. Zheng, Z. Yin, Y. Wu, Y. Xu, Y. Luo, T.C. Zhang LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhi...
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent genes, promotes lung metastasis, and tha...
Cancer Cell International(2024) Dyads of GGC and GCC form hotspot colonies that coincide with the evolution of human and other great apes M. Arabfard N. Tajeddin M. Ohadi BMC Genomic Data(2024) Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response ...