In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Abstract Thousands of unique non-coding RNA (ncRNA...
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs (ncRNAs) with a minimum length of 200 nucleotides, which have been well studied in the context of RNA-based therapeutics [13,14]. Although only a small fraction of known lncRNAs have been functionally characterized, there is growing...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently...
Circular RNA (circRNA) from backspliced exons is a type of covalently closed noncoding RNA that may regulate gene expression in eukaryotes. The recent application of RNA sequencing and bioinformatics approach has revealed a large number of circRNAs in various cell lines and across different species....
The Role of Non-coding RNAs in Oncology Abstract: Meta Translation 标题:非编码RNA在肿瘤学中的作用 作者:弗兰克·J·斯拉克;阿鲁尔·M·钦内亚安;B·D·亚当斯;A·L·卡辛斯基;F·J·斯拉克;B·D·亚当斯;C·帕森斯;F·J·斯拉克 摘要:本文综述了非编码RNA在肿瘤学中的重要作用。非编码RNA是一类不参与...
Studies have found that RNA encoding proteins only account for a small part of the total number, most RNA is non-coding RNA, and non-coding RNA may affect
The long and the short of noncoding RNAs. Curr Opin Cell Biol. 2009;21(3):416–25. Article CAS PubMed Google Scholar Gibb EA, Brown CJ, Lam WL. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011;10(1):38–55. Article CAS PubMed PubMed Central ...
Noncoding RNA pre-mRNA: Pre-messenger RNA snRNPs: Small nuclear ribonucleoprotein ISE: Intron splicing enhancer ISS: Intron splicing silencer ESE: Exon splicing enhancer ESS: Exon splicing silencer ES: Exon skipping IR: Intron retention MXE: ...
CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment CRNDEis the gene symbol forColorectal Neoplasia Differentially Expressed (non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses multiple ... BC Ellis,PL Molloy,LD Graham - 《Frontiers in Genetics》...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re