ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes,...
Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1. J Natil Cancer Inst 2011; 103: 1713–1722. CAS Google Scholar Matouk IJ, DeGroot N, Mezan S, Ayesh S, Abu-lail R, Hochberg A et al. The H19 non-coding RNA is essential for human tumor ...
Long noncoding RNA levels may have a higher correlation with particular cancer states and thus be more useful diagnostic tools. Noncoding RNAs are often stable in human serum and thus measuring either individual marker RNAs (e.g., by qPCR) or the entire transcriptome (e.g., RNA-seq) may ...
Endo-siRNA, endogenous small-interfering RNA; lncRNA, long non-coding RNA; MiRNA, microRNA; piRNA, PIWI-interacting RNA; sdRNA, sno-derived RNA; sncRNA, small non-coding RNA; snoRNA, small nucleolar RNA. In general, ncRNAs are grouped into two major classes based on their length. Those ...
TheCDKN2A/Bgenomic locus is associated with risk of human cancers and metabolic disease. Although the locus contains several important protein-coding genes, studies suggest disease roles for a lesser-known antisense lncRNA encoded at this locus, calledANRIL.ANRILis a complex gene containing at least...
Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression Mol. Cancer Ther., 14 (2015), pp. 268-277 View in ScopusGoogle Scholar 32 Z. Chen, X. Chen, P. Chen, S. Yu, F. Nie, B. Lu, T. Zhang, Y...
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through...
Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2. J Hematol Oncol. 2015;8... Ming-de,Huang,Wen-Ming,... - 《Journal of Hematology & Oncology》 被引量: 101发表: 2015年 Long non-coding RNAs as an Epigenetic ...
With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-coding signaling pathways underlie various biologi...
et al. Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget 5, 2276–2292 (2014). PubMed PubMed Central Google Scholar Esteller, M. Non-coding RNAs in human disease. Nat. Rev. Genet....