MicroRNAs, very short non-coding RNAs, are abnormally expressed in cancer and some harbor mutations that affect expression levels. MicroRNA alterations have been observed in all forms of cancer that have been researched to the current date. MicroRNAs are also located in cancer- associated genomic ...
Understanding the mechanisms that regulate gene expression during cancer development is of paramount importance for the development of effective therapeutic regimens. The discovery of miRNAs, a class of noncoding RNA genes with a role in gene silencing [1-3], caused a dramatic increase in research ...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently...
In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Abstract Thousands of unique non-coding RNA (ncRNA...
Long non-coding RNAs (LncRNAs) are RNA molecules with more than 200 nucleotides in length. LncRNAs can be divided into sense, antisense, bidirectional, intronic or intergenic according to their proximity to the nearest known protein-coding genes (Fig. 1). LncRNAs have no or limited protein codi...
Functional variations in coding and noncoding RNAs are crucial in tumorigenesis, with cancer-specific alterations often resulting from chemical modifications and posttranscriptional processes mediated by enzymes. These RNA variations have been linked to tumor cell proliferation, growth, metastasis, and drug...
The Role of Non-coding RNAs in Oncology Abstract: Meta Translation 标题:非编码RNA在肿瘤学中的作用 作者:弗兰克·J·斯拉克;阿鲁尔·M·钦内亚安;B·D·亚当斯;A·L·卡辛斯基;F·J·斯拉克;B·D·亚当斯;C·帕森斯;F·J·斯拉克 摘要:本文综述了非编码RNA在肿瘤学中的重要作用。非编码RNA是一类不参与...
Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol. 2013; 34:613-20. https://doi.org/10.1007/s13277-013-0658-6.Qiu MT, Hu JW, Yin R, et al. 2013. Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol 34:613-620....
这是一篇发表在“Cancer Letters”上的mini review,文章总结了关于三种非编码RNA(miRNAs/lncRNAs/circRNAs)在癌症研究中常用的网络资源,这里跟大家一起看一下。因为里面提及的网络资源有点多,所以,我就按RNA种类分别给大家介绍。 惯例,先给出文章 A comprehensive review of web-based non-coding RNA resources ...
研究结果以“Systematic Identification of Non-coding pharmacogenomic landscape in cancer”为题发表在《Nature Communications》杂志上。 LncRNA是一类长度超过200个核苷酸的ncRNA,少部分lncRNA在肿瘤细胞生长、迁移及耐药发生中的关键调控作用已被多次报道1-7,但人们对于大部分lncRNA在肿瘤细胞中的调控作用仍缺少系统的认...