In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Abstract Thousands of unique non-coding RNA (ncRNA...
New insights into non-coding RNA networks in Huntington's disease Identify six causal miRNAs of breast cancer.Four miRNA-mRNA modules have classification ability of breast cancer.The classification performance of module i... BR Johnson - 《Experimental Neurology》 被引量: 5发表: 2011年 LncmiRSRN...
Cancer development and progression include many cellular processes, among which cellular signaling networks play crucial roles. The hallmarks of cancer cells are gained through the deregulation of these signaling pathways, which result in the evasion of apoptosis, invasion, angiogenesis, metastasis, and ...
Carcinogenesis is a multistep process in which normal cells acquire genetic and epigenetic alterations that drive the onset of “hallmarks” of cancer finally resulting in development and progression of malignancies [1]. Despite most cancer studies have been focused on protein-coding genes, the eviden...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
The RNA components of the spliceosome, uridine-rich (U) snRNAs, can regulate tissue-specific and cancer-specific alternative splicing [53]. Notably, recurrent mutations in U1 snRNA, as one of the most abundant noncoding RNAs, have been recently identified in multiple cancer types and play an ...
这是一篇发表在“Cancer Letters”上的mini review,文章总结了关于三种非编码RNA(miRNAs/lncRNAs/circRNAs)在癌症研究中常用的网络资源,这里跟大家一起看一下。因为里面提及的网络资源有点多,所以,我就按RNA种类分别给大家介绍。 惯例,先给出文章 A comprehensive review of web-based non-coding RNA resources ...
研究结果以“Systematic Identification of Non-coding pharmacogenomic landscape in cancer”为题发表在《Nature Communications》杂志上。 LncRNA是一类长度超过200个核苷酸的ncRNA,少部分lncRNA在肿瘤细胞生长、迁移及耐药发生中的关键调控作用已被多次报道1-7,但人们对于大部分lncRNA在肿瘤细胞中的调控作用仍缺少系统的认...
Non-coding RNA Function Cancer Development Diagnosis Therapy 1. Introduction High-throughput technologies have allowed the discovery ofRNAtranscripts that do not encode for proteins, known as "non-coding RNA (ncRNAs)," which are ncRNAs in about 98% of thehuman genomeafter transcription[1]. NcRNAs...
In the past few years, an accumulating body of evidence has deepened our understanding of ncRNAs, and several emerging ncRNAs have been identified, such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). The competing endogenous RNA (ceRNA) networks include mRNAs, microRNAs, long ...