In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Abstract Thousands of unique non-coding RNA (ncRNA...
CYP3A4, an enzyme involved in drug metabolism, was validated as a target, establishing a possible link between the vault RNA and multi-drug resistance. Finally, we used microarrays to show that miRNA expression efficiently separates clinically relevant subgroups of bladder cancer. In summary, we ...
10,11]. The ncRNAs have cell type, tissue and cancer specificity, thus RNA profiling has become a mean to identify useful biomarkers of tumor development, progression and metastasis. Although miRNAs represent the most widely investigated ncRNAs, lncRNAs are emerging as cancer key regulators [7,12]...
事实上,RNA药物领域经历了复兴(Levin,2019年),最近获批了第一种RNAi药物Onpattro(patisiran;用于治疗遗传性转铁蛋白淀粉样变性的TTR水平)(Adams等,2018年),以及RNA靶向寡核苷酸药物Spinraza(nusinersen;用于增加治疗神经肌肉疾病脊髓性肌肉萎缩的全长SMN2水平)的临床成功(Wurster等,2019年)。此外,基于一类称为微小RNA(...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
cancers Review New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis Yutong Sun 1 and Li Ma 2,* 1 Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ysun2@mdanderson.org 2 Department of Experimental ...
Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer Long noncoding RNAs (lncRNAs) increase in genomes of complex organisms and represent the largest group of RNA genes transcribed in mammalian cells. Previou... J Erber,D...
CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment CRNDEis the gene symbol forColorectal Neoplasia Differentially Expressed (non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses multiple ... BC Ellis,PL Molloy,LD Graham - 《Frontiers in Genetics》...
Sign in to set up alerts select article Membrane-lipid associated lncRNA: A new regulator in cancer signaling Mini reviewAbstract only Membrane-lipid associated lncRNA: A new regulator in cancer signaling Yanxiu Ma, Junmei Zhang, Lixia Wen, Aifu Lin ...
研究结果以“Systematic Identification of Non-coding pharmacogenomic landscape in cancer”为题发表在《Nature Communications》杂志上。 LncRNA是一类长度超过200个核苷酸的ncRNA,少部分lncRNA在肿瘤细胞生长、迁移及耐药发生中的关键调控作用已被多次报道1-7,但人们对于大部分lncRNA在肿瘤细胞中的调控作用仍缺少系统的认...