Intriguingly, more than 85% of single nucleotide polymorphisms identified as disease-associated by genome-wide association studies (GWAS) occur in non-coding regions.The relatively recent discovery of widespread transcription of potentially functional long non-coding RNAs (lncRNAs) led us to investigate ...
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 bp and have little or no protein-coding capacity. Once considered as transcriptional noise, significant numbers of lncRNAs have now been identified as modulators of gene expression and functions, and are implicated in a range of devel...
Long noncoding RNAs (LncRNAs) are generally defined as transcripts longer than 200 nucleotides, but are not protein-coding [4]. Numerous studies have indicated that LncRNAs are involved in almost every cellular process and several human diseases, including ischemic stroke, diabetic complications and ...
环状RNA(Circular RNA):noncoding RNAs的新明星分子 circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA...
Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and disease. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expression and function of lncRNAs in the developing hu...
LncRNA (Long non-coding RNA) is a class of non-coding RNA molecules with lengths exceeding 200 nucleotides and lacking protein-coding functions.
Long intergenic non-coding RNAs (lincRNAs) play essential roles in numerous biological processes and are widely studied. The skeletal muscle is an important tissue that plays an essential role in individual movement ability. However, lincRNAs in pig skeletal muscles are largely undiscovered and thei...
RNAs, small nucleolar and tRNAs derived small RNAs, other types of small RNAs, such as those associated with splice junctions and transcription start sites, long non-coding RNAs, including antisense RNAs, long 'intergenic' RNAs, intronic RNAs and 'enhancer' RNAs, other classes of RNAs such as...