New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibilit
Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4and CD8T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria鈥攖wo...
别名 natural killer cell granule protein 7 , GIG1 , GMP-17 , p15-TIA-1 细胞定位 Cell membrane 数据库 Gene ID:4818NKG7 UniProt:Q16617NKG7 研究领域 细胞生物学 细胞生物学 细胞凋亡 免疫学 免疫学 先天免疫学 细胞器标记 细胞器标记 溶酶体 ...
Furthermore, NKG7 mRNA is expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B cells, monocytes, and ...