在小鼠CD8 T细胞中,NKG2D表达在TCR激活后上调(扩展数据图4d)。由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要因素。为了初步评估这一点,作者首先检查了模型中T细胞上的NKG2D表达。因此,作者检查了未经处理的小鼠中...
由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要因素。为了初步评估这一点,作者首先检查了模型中T细胞上的NKG2D表达。因此,作者检查了未经处理的小鼠中浸润CT2A-TRP2或CT2A-TRP2-β2mKO胶质瘤的CD8 T细胞上NKG2D...
由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要因素。为了初步评估这一点,作者首先检查了模型中T细胞上的NKG2D表达。因此,作者检查了未经处理的小鼠中浸润CT2A-TRP2或CT2A-TRP2-β2mKO胶质瘤的CD8 T细胞上NKG2D...
NKG2D,cytotoxic T cellTOXtumor microenvironmentFor successful immunotherapy for cancer, it is important to understand the immunological status of tumor antigen-specific CD8+T cells in the tumor microenvironment during tumor progression. In this study, we monitored the behavior of B16OVA-Luc cells in ...
机制研究揭示,CD4+ T28zT2细胞通过阻断TGFβ1诱导的线粒体分裂和膜电位抑制维持效应功能,同时通过CXCR3高表达促进肿瘤浸润,NKG2D的上调则精准递送杀伤因子以避免全身毒性。基于这一突破,团队已启动相关临床研究(NCT03198052),旨在评估“C...
Natural killer group 2 member D (NKG2D) is a type II transmembrane receptor. NKG2D is present on NK cells in both mice and humans, whereas it is constitutively expressed on CD8+ T cells in humans but only expressed upon T-cell activation in mice. NKG2D i
NKG2D+ IFN-γ+ CD8+ T Cells Are Responsible for Palladium Allergy doi:10.1371/journal.pone.0086810Nickel, cobalt, and chromium are well known to be causal agents of allergic contact dermatitis. Palladium (Pd) can also cause allergic disease and exposure results from wide use of this metal in...
抗肿瘤免疫调节作用,NKG2D+CD8NKT细胞的功能取决于 表面活化性受体NKG2D[].可溶性人类主要组织相容性复 合体(MHC)一I类分子链相关基因A蛋白(sMICA)是NKG2D 的配体。故探索NKG2D+CD8+NKT细胞及血清sMICA在肺癌 患者体内的表达情况,及两者之间的关系有重要的意义。
(NKG2D). NKG2D, encoded byKlrk1, is an activating cell surface receptor that is predominantly expressed on Natural killer cells [38,39]. NKG2D is abundantly present on all NK cells, NKT cells, and subsets ofγδT cells [40]. While naïve human CD8+T cells express NKG2D, in mice CD8 ...
Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction. Int J Cancer 2012;131(7):1601-10.André MC, Sigurdardottir D, Kuttruff S, Pömmerl B, Handgretinger R, Rammensee HG, Steinle A. Impaired tumor rejection by memory CD8 T cells in mice w...