CD8 expression on the NK cells is associated with the effective cytotoxicity against K562 but at the same time obstructs a response to MOLT4. CD8伪伪 on NK cells might participate in HLA recognition or enhance response to HLA class-I negative target cells.Dons'koi, B. V....
NK cells, expression of the human CD8 transgene on mouse NK cells is appropriate since CD8 is expressed on a subset of human NK cells, Deletion of the intronic enhancer resulted in a complete loss of transgene expression in most lines and a loss of expression only in NK cells in one line...
panNK (CD49b+) cells were magnetically enriched and used in the subsequent analyses (Fig. 1a). NKT cells can be divided into three subsets based on CD8 expression and affinity to an α-GalCer-loaded CD1d tetramer: Tetramer−CD8−NKT cells, Tetramer−CD8+NKT (CD8+NKT...
NK cells limited autologous CD8+ T cell immunity in an effector/target ratio manner. The suppression was dependent on the existence of NKG2D. We also observed upregulated MICA expression on activated CD8+ T cells, which were susceptible to NK cell mediated lysis in SAA. Animal model concurred ...
T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. T regulatory cells control numbers of NK cells and CD8alpha + immature dendritic cells in the lymph node paracortex. J Immunol. 2007; 179 :4492–4502... M Giroux,E Yurchenko...
Natural killer group 2 member D (NKG2D) is a type II transmembrane receptor. NKG2D is present on NK cells in both mice and humans, whereas it is constitutively expressed on CD8+ T cells in humans but only expressed upon T-cell activation in mice. NKG2D i
NK1.1CD8T cells are derived from CD8T cells during priming, and their differentiation is inhibited by transforming growth factor-β signalling. After their own contraction phase, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both interferon-γ and ...
John Wherry研究团队题为LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity的研究文章。这三项研究从临床数据和实验室分析同时揭示PD-...
CD8+T细胞是抗肿瘤免疫的关键效应细胞,用IL-2刺激可诱导其增殖并增强效应功能,相比之下,NK细胞已在临床前模型中被证明会导致基于IL-2的治疗毒性,且对于抗肿瘤活性来说是可有可无的【4, 5】,因此,用IL-2特异性靶向CD8+T细胞并远离...
1+CD3+ T cells that expresses an invariant TCR has been named "NKT cells." Here, we describe NK marker expression on a broad spectrum of MHC class I- and MHC class II-restricted T cells that are induced after acute viral infection. From 5 to >500 days post lymphocytic choriomeningitis ...