特别是在CD8 T细胞中,NKG2D细胞效应似乎依赖于同时的TCR激活,以将效应活性限制在适当的周围靶标上。在小鼠CD8 T细胞中,NKG2D表达在TCR激活后上调(扩展数据图4d)。由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要...
特别是在CD8 T细胞中,NKG2D细胞效应似乎依赖于同时的TCR激活,以将效应活性限制在适当的周围靶标上。在小鼠CD8 T细胞中,NKG2D表达在TCR激活后上调(扩展数据图4d)。由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要...
特别是在CD8 T细胞中,NKG2D细胞效应似乎依赖于同时的TCR激活,以将效应活性限制在适当的周围靶标上。在小鼠CD8 T细胞中,NKG2D表达在TCR激活后上调(扩展数据图4d)。由于作者模型中CD8 T细胞介导的MHC-I阴性肿瘤杀伤也依赖于TCR激活,但不需要T细胞与肿瘤细胞之间的抗原配对相互作用,作者假设NKG2D可能是肿瘤杀伤机制的重要...
Natural killer group 2 member D (NKG2D) is a type II transmembrane receptor. NKG2D is present on NK cells in both mice and humans, whereas it is constitutively expressed on CD8+ T cells in humans but only expressed upon T-cell activation in mice. NKG2D i
作为一种活性受体，NKG2D可以在人类和小鼠的NK细胞、CD8+T细胞和其他免疫活性细胞中表达，但在CD4+T细胞中通常不表达[3]。Figure 2. The gene structure of human NKG2D*This diagram is derived from reference 1.2、NKG2D的配体与其他NKG2受体不同，NKG2D拥有多种配体，包括人类MHC-I类链相关分子（MICA和MICB）...
Functions of NKG2D in CD8(+) T cells: an opportunity for immunotherapy. Cell Mol Immunol. (2018) 15:470-9. doi: 10.1038/cmi.2017.161Prajapati K, Perez C, Rojas LBP, Burke B, Guevara-Patino JA. Functions of NKG2D in CD8(+) T cells: an opportunity for immunotherapy. Cell Mol ...
NKG2D is an activating receptor that stimulates innate immune responses by natural killer cells upon engagement by MIC ligands, which are induced by cellular stress. Because NKG2D is also present on most CD8 T cells, it may modulate antigen-specific T cell responses, depending on whether MIC ...
[11] Kavazović, I.; Lenartić, M.; Jelenčić, V.;et al. NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice [J]. Eur. J. Immunol. 2017, 47, 1123–1135. ...
ULBP1蛋白可以通过结合NKG2D激活NK细胞、CD8+ T细胞和γδT细胞，从而参与免疫监视和免疫清除的过程。已有研究证实，NKG2D和ULBP1配体在多种肿瘤中相互作用，在免疫细胞靶向并杀伤细胞中起重要作用 [6]。图2. 人和鼠NKG2D ligands的结构 [5]3. ULBP1在NKG2D/NKG2DL系统中的作用机制 大量研究已揭示，NKG2D/NKG2DL...
CD8 T cells with polycytokine capability, specifically with the ability of CD8 T cells to co-produce IFNγ, TNFα and IL-2. The presence of these polycytokine-producing CD8 T cells correlates strongly with protection against foreign pathogens and cancer. Therefore, approaches capable of inducing...