27. 216 Dual targeting of CAR-NK cells to PD-L1 and ErbB2 facilitates specific elimination of cancer cells of solid tumor origin and overcomes immune escape by antigen loss. Jiri Eitler et al.28. NK Cell Metabolism and TGFβ - Implications for Immunotherapy. [PMID: 31921174]29. Cordycep...
infiltrated in 10 cases, while a few large cells infiltrated in 6. Immunohistochemistry showed the infiltrated lymphocytes were CD3+CD56+ in 2 cases,CD3+CD8+ in 11 cases and CD3+CD4+ in 3 cases . TIA-1 and EBER were positive in all biopsy specimens. 3 cases underwent biopsy oflymphonodes...
NKG2D can respond to MICA/B on the tumor cell surface, potentially reducing the probability of immune escape and reversing the immunosuppressive effects [11]. Antigen loss, often caused by downregulation or mutation of target antigens shed on tumor cell surfaces, limits CAR function during tumor ...
In recent decades, adoptive cell therapies have emerged as promising approaches for harnessing the endogenous cytotoxicity of immune cells and destroying malignant cells. Among immune cell candidates, natural killer (NK) cells have drawn significant attention due to their unique ability to recognize and ...
engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes, which broadens the range of target peptides. Indirect tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and signaling. Indeed, ...
NK92 cells were engineered to express this third-generation of dtCAR. We then elucidated the role of dtCAR-modified NK92 cells against cancer cells in vitro and in vivo. Results In vitro, the dtCAR-NK92 cells could still retain the characteristics of parental NK cells and exhibit improved...
杨凡-T细胞及NK细胞肿瘤流式细胞分析
Although CAR-NK cells hold great promise as a future “off-the-shelf” drug, there are NK cell-specific challenges, such as potential loss of viability and/or activity with freeze–thaw process and lack of in vivo persistence. To circumvent these challenges, Bi- and tri-specific killer engag...
2. NK cells: From a function to a multifaceted population 2.1 The discovery of NK cells NK cells were originally identified on a functional basis. In the middle '70s, it was discovered that healthy individuals could display selective cytotoxic activity against tumor or virally infected cells and...
cells through multiple mechanisms of action [18]. The traditional dogma, by which NK recognition of abnormal cells is primarily driven by loss of target MHC-I surface expression, has over time been expanded by a more subtle understanding of the complex integration of multiple stimuli from both ...