Methods of identifying agents that selectively activate p38 and/or NKkB signalingThe present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple pathways. The method includes exposing the receptor ...
MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer Theranostics (IF=7.032) Published online 2021 研究背景: NF-κB家族由五个成员组成:RelA/p65、RelB、c-Rel、p50/p105和p52/p100。NF-κB信号的典型激活主要是通过p65和p50的异二聚体作为NF-κB靶基因的转录因子。 肺癌...
The fluorochrome-conjugated Abs were used in the flow cytometric analyses: a-pS536 p65-Alexa Fluor 488 (93H1) and isotype control rabbit IgG-Alexa Fluor 488 (DA1E; Cell Signaling); a-CD3- PerCP (SK7), a-CD56-PE (NCAM16.2), a-CD107a-FITC (H4A3), a-IFN-g-FITC (25723.11), a...
Methods of identifying agents that selectively activate p38 and/or NKkB signalingThe present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple pathways. The method includes exposing the receptor ...