The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number ...
1. NF-κB activation via tumor necrosis factor (TNF) Nuclear factor kappa B (NF-κB) was discovered by David Baltimore's laboratory as an inducible transcription factor in lymphocytes [1]. The so-called canonical pathway of NF-κB activation via tumor necrosis factor (TNF) [2], [3] will...
The NF-kappaB family of transcription factors responds to inflammatory cytokines with rapid transcriptional activation and subsequent signal repression. Much of the system control depends on the unique characteristics of its major inhibitor, IkappaBalpha, which appears to have folding dynamics that underli...
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and drives malignant transformation through mainte
Paricalcitol (Pari) EAE Inflammation NF-κB 1. Introduction Multiple sclerosis (MS) is an autoimmune disease, which is characterized by inflammation, demyelination, as well as axonal degeneration in the central nervous system (CNS) [1,2]. The clinical course of MS is significantly heterogeneous, ...
1550 NW 10 Avenue, Miami, FL 33136, USA; 2Department of Physiological Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions including innate and adap- tive immunity and cell survival...
Cadmium accumulated in cultured astrocytes and stimulated inflammatory factor release via the mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) pathways[6]. Sub-toxic concentrations of heavy metals led to dysfunctional oligodendrocytes[7]. Therefore, brain cells other than...
Tuberculosis (TB) is a zoonotic infectious disease caused by Mycobacterium tuberculosis (Mtb). Apoptosis and necrosis caused by the interaction between the host and the pathogen, as well as the host’s inflammatory response, play an important role in the
migration and apoptosis via the COMPASS complex and NF-κB signaling Zhao Liu1, Jiuzheng Sun1, Chuanzhi Li1, Liyou Xu1 and Jun Liu2,3* Abstract Background: Histone modification plays essential roles in hepatocellular carcinoma (HCC) pathogenesis, but the regulatory mechanisms remain poorly under...
Among the IκB family members, IκBζ, IκBNS and Bcl-3 are nuclear proteins bound to a NF-κB subunit. IκBζ is weakly expressed but markedly induced in response to TLR ligands and IL-1β, but not to TNF-α, via the MyD88-dependent pathway [62]. IκBζ-deficient macrophages pr...