The activation of the nuclear factor kappa B (NF-κB) family of transcription factors is a key step in the adaptive immune response, in which lymphocytes respond to antigen by proliferating and generating multiple effector responses geared toward eradicating a pathogen. NF-κB activation is required...
In mammalian cells, there are five members of the NF-κB family: RelA (p65), RelB, C-Rel, p105 (NF-κB1; a precursor of p50) and p100 (NF-κB2; a precursor of p52) (Figure 2). NF-κB proteins form homo- or hetero-dimers and TIR-domain-containing adaptors Subsequent to ...
An Essential Role for EGFR in Glutamate Receptor Signaling to NF-{kappa}BSitcheran, RComb, WCogswell, PBaldwin, ASitcheran R, Comb WC, Cogswell PC, Baldwin AS. An essential role for EGFR in glutamate receptor signaling to NF-{kappa}B. Mol Cell Biol. 2008 (in press)....
S1576SulfasalazineSulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor ofnuclear factor kappa B (NF-κB),TGF-βandCOX-2. Sulfasalazine inducesferroptosis,apoptosisandautophag...
Here, we present a systems biology approach that combines transcriptomic and structural analyses with live-cell imaging to predict small molecule inhibitors of TNF-induced NF-κB signaling and elucidate the network response. We identify two first-in-class small molecules that inhibit the NF-κB ...
Interactive NF-κB signalling pathway depicting the regulation of NF-κB in response to inflammation, immune and cell stress. Targets lead to related information and Tocris products.
They are ac- tivated in response to ligation of many receptors includ- ing T-cell receptors, B-cell receptors, members of the tumor necrosis factor (TNF) receptor superfamily and the Toll-like receptor/interleukin-1 receptor (TLR/IL- 1R) superfamily. Mammalian, viral and drosophila NF- κB...
Together these findings indicate that, although both of these receptors lead to the activation of NF-kappaB, they proceed via distinct proximal-signaling intermediates and contribute to different cellular outcomes. 展开 关键词: TrkA p75 NGF NF-kappa B IKK PC12 cells apoptosis neurite process ...
Neuronal viability is maintained through a complex interacting network of signaling pathways that can be perturbed in response to a multitude of cellular stresses. A shift in the balance of signaling pathways after stress or in response to pathology can
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