Crosstalk in NF-[kappa]B signaling pathwaysOeckinghausHaydenGhosh
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382(Pt 2):393–409. Article Google Scholar Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293:1495–1499. ...
Crosstalk in NF-[kappa]B signaling pathways Crosstalk of reactive oxygen species and NF-|[kappa]|B signaling Networks and crosstalk: integrin signalling spreads. Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Hormone crosstalk in plant disease and defense: more than just...
Guillermet-Guibert J,Saint-Laurent N,Davenne L,et al.Novel synergistic mechanism for sst2 somatostatin and TNF al- pha receptors to induce apoptosis:crosstalk between NF-kappa B and JNK pathways.Cell Death and Differentiation. 2007Guillermet-Guibert J , Saint-Laurent N , Davenne L , et al...
The phenomenon of cell death has garnered significant scientific attention in recent years, emerging as a pivotal area of research. Recently, novel modalities of cellular death and the intricate interplay between them have been unveiled, offering insight
(PTMs), which are triggered by different carcinogenic factors and signaling pathways, with small ubiquitin-like modifier (SUMOylation) emerging as a particularly pivotal player in this context. Recent studies have demonstrated that SUMOylation does not act alone, but interacts with other PTMs, ...
We further demonstrate that IFITM1 expression is regulated by enhanced IFNα and NFκB signaling which can be targeted by the naturally derived compound, parthenolide. Collectively, our data suggest that a subset of TNBC tumors overexpress IFITM1 and that targeting IFITM1 in these tumors might be...
Two types of NF-κB signaling pathways have been identified. p50 (NF-κB1)/p65 (RelA) enters the nucleus and binds to IFN or cytokine promoters. Nuclear translocation is performed using p52/RelB, although in a noncanonical manner. The dimeric complex of NF-κB responds to several stimuli, ...
STING subsequently recruits and activates TANK-binding kinase 1 (TBK1) to initiate downstream signaling, which in turn promotes the phosphorylation of interferon (IFN) regulatory factor 3 (IRF3), while STING promotes nuclear factor-kappa B (NF-κB) phosphorylation by activating IκB kinase (IKK)....
The phenomenon of cell death has garnered significant scientific attention in recent years, emerging as a pivotal area of research. Recently, novel modalities of cellular death and the intricate interplay between them have been unveiled, offering insight