Crosstalk in NF-[kappa]B signaling pathwaysOeckinghausHaydenGhosh
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382(Pt 2):393–409. Article Google Scholar Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293:1495–1499. ...
Crosstalk in NF-[kappa]B signaling pathways Crosstalk of reactive oxygen species and NF-|[kappa]|B signaling Networks and crosstalk: integrin signalling spreads. Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Hormone crosstalk in plant disease and defense: more than just...
such as Fas, TNFR1, IFNRs, TLRs, or DNA-sensing molecules like ZBP1/DAI. In the TNFR1-dependent pathway, TNF-α binds to TNFR1, forming complex I (DISC) where RIPK1 is polyubiquitinated by cIAP1 or LUBAC, activating NF-κB signaling to promote cell survival. When NF-κB ...
TLR4 uses both the MyD88-dependent or the TRIF-dependent signaling pathways. Activation of TLR signaling leads to the translocation of nuclear factor kappa light chain enhancer of activated B cells (NF-κB), interferon regulatory factors (IRFs), or transcription factor activator protein 1 (AP-1...
IKK complex phosphorylates and degrades IkB, a NF-κB inhibitor, consequently activating NF-κB signaling pathways and cell survive [46]. In instances when NF-κB activation is suppressed, deubiquitinated RIPK1, Fas-associated protein with death domain (FADD), TRADD, and pro-caspase-8 assemble ...
We further demonstrate that IFITM1 expression is regulated by enhanced IFNα and NFκB signaling which can be targeted by the naturally derived compound, parthenolide. Collectively, our data suggest that a subset of TNBC tumors overexpress IFITM1 and that targeting IFITM1 in these tumors might be...
Enhanced activation of Akt, IκBα, ERK, p38, and JNK, as well as nuclear transport of NF-κB subunit p65, were observed in the MRL/lpr cells Discussion Accumulating evidence has demonstrated that defects in signaling pathways make significant contributions to autoimmune diseases [18]. MRL/lpr...
Gnotobiotic IL-10 À / À ;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J. Immunol. 178, 6522–6532 (2007). 19. Kim, S. C., Tonkonogy, S. L., Karrasch, T., Jobin, C. & Sartor, R. B. Dual-...
(PTMs), which are triggered by different carcinogenic factors and signaling pathways, with small ubiquitin-like modifier (SUMOylation) emerging as a particularly pivotal player in this context. Recent studies have demonstrated that SUMOylation does not act alone, but interacts with other PTMs, ...