The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number ...
2008. Crosstalk via the NF-kappaB signaling system. Cytokine and Growth Factor Reviews 19:187-197.Basak S, Hoffmann A. Crosstalk via the NF-kappa B ... BA Hoffmann - 《Cytokine & Growth Factor Reviews》 被引量: 387发表: 2008年 Beyond IκBs: alternative regulation of NF‐KB activity Cro...
NF-κB pathway Since its discovery as a nuclear factor that binds to DNA elements in the intronic enhancer of the kappa light chain gene of B cells, NF-κB has been investigated for its function as a transcription factor [22]. The NF-κB network consists of seven family members: p105/p50...
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Vargas, A. Hoffmann Signaling via the NFkappaB system Wiley Interdiscip. Rev. Syst. Biol. Med., 8 (3) (2016), pp. 227-241, 10.1002/wsbm.1331 View in ScopusGoogle Scholar [33] F. Salamone, F. Galvano, F. Cappello, A. Mangiameli, I. Barbagallo, G. Li Volti Silibinin modulates ...
NF-κB神经元突触突触传递Ca(2+)-regulated gene transcription is essential to diverse physiological processes, including the adaptive plasticity associated with learning. We found that basal synaptic input activates the NF-kappa B transcription factor by a pathway requiring the Ca(2+)/calmodulin-...
Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still un
Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
162 Hence, more studies are needed to explore the comprehensive role of IL-33 in psoriasis. Intracellular signaling pathways of transmission The NF-κB pathway One of the features of psoriasis is the elevated level of active, phosphorylated nuclear factor kappa B (NF-κB).128 NF-κB, a ...
Obesity is a complex, chronic disease and global public health challenge. Characterized by excessive fat accumulation in the body, obesity sharply increases the risk of several diseases, such as type 2 diabetes, cardiovascular disease, and nonalcoholic f