The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number ...
The transcription factor NF-κB was discovered in 1986 as a nuclear factor that binds to the enhancer element of the immunoglobulin kappa light-chain of activated B cells (thereby coining the abbreviation NF-κB) [1]. Soon afterwards it became clear that proteins, which harbor this specific DNA...
NF-kappa B is a critical nuclear transcriptional factor that is activated in response to cellular stresses and regulates the expression of genes involved in cell proliferation and cell death. When regulated NF-kappa B activation is disrupted, cells undergo apoptosis. That is, constitutively elevated ...
Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Nakamura T, et al .: Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcino......
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and drives malignant transformation through mainte
Crosstalk via the NF-κB signaling system. Cytokine Growth Factor Rev 2008; 19:187–197. Article CAS PubMed PubMed Central Google Scholar Huxford T, Huang DB, Malek S, Ghosh G . The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-κB inactivation. Cell ...
Scar formation as a result of corneal wound healing is a leading cause of blindness. It is a challenge to understand why scar formation is more likely to occur in the central part of the cornea as compared to the peripheral part. The purpose of this stud
TNF-α has long been known to induce nuclear factor-kappa B, NF-κB, signaling by, in most cases, translocating the p65 (RelA) DNA binding factor to the nucleus. p65 is a key member of NF-κB, which is well established as a family of transcription factors that regulates many signaling...
A20-mediated negative regulation of canonical NF-κB signaling pathway The nuclear factor kappa B (NF-kappa B) plays vital role in the immune system by regulating innate and adaptive immunity, development and survival of lymph... R Pujari,R Hunte,WN Khan,... - 《Immunologic Research》 被引...
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382: 393–409. CAS PubMed PubMed Central Google Scholar Vallabhapurapu S, Karin M . Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27: 693–733. ...