The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number ...
Nuclear factor kappa B (NF-κB) was discovered by David Baltimore's laboratory as an inducible transcription factor in lymphocytes [1]. The so-called canonical pathway of NF-κB activation via tumor necrosis factor (TNF) [2], [3] will be presented to summarize part of the general knowledge...
Paricalcitol (Pari) EAE Inflammation NF-κB 1. Introduction Multiple sclerosis (MS) is an autoimmune disease, which is characterized by inflammation, demyelination, as well as axonal degeneration in the central nervous system (CNS) [1,2]. The clinical course of MS is significantly heterogeneous, ...
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and drives malignant transformation through mainte
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001; 7:401–409. Article CAS PubMed Google Scholar Dejardin E, Droin NM, Delhase M, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity ...
Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still un
Bmi-1 induced aggressiveness in glioma cells via the NF-kappaB/MMP-9 pathway Next, we examined whether Bmi-1 increased the aggressiveness of glioma cells via activation of the NF-kappaB signaling pathway. The increased migratory and invasive ability of Bmi-1-overexpressing glioma cells were dramati...
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlying USP16 gene expression, USP16 gene promoter
migration and apoptosis via the COMPASS complex and NF-κB signaling Zhao Liu1, Jiuzheng Sun1, Chuanzhi Li1, Liyou Xu1 and Jun Liu2,3* Abstract Background: Histone modification plays essential roles in hepatocellular carcinoma (HCC) pathogenesis, but the regulatory mechanisms remain poorly under...
NF-kappa B is a critical nuclear transcriptional factor that is activated in response to cellular stresses and regulates the expression of genes involved in cell proliferation and cell death. When regulated NF-kappa B activation is disrupted, cells undergo apoptosis. That is, constitutively elevated ...