本文是针对论文《NK细胞和实体瘤：治疗潜力和持续存在的障碍（NK cells and solid tumors: therapeutic potential and persisting obstacles）》该综述于2022年11月发表于Molecular Cancer。背景介绍 前言：自然杀伤（NK）细胞是具有强大细胞毒性活性的先天性淋巴细胞，它作为潜在的抗癌疗法引起关注，但NK细胞输注在实体瘤...
肿瘤被高度可塑和功能异质性的CAFs种群浸润,它可以直接抑制免疫效应细胞,通过产生大量TGFB1或者下调PVR细胞(NK细胞受体之一)粘附性,抑制NK细胞功能。 原文链接: https://pubmed.ncbi.nlm.nih.gov/36319998/#:~:text=NK%20cells%20and%20solid%20tumors%3A%20therapeutic%20potential%20and,have%20recently%20attra...
肿瘤被高度可塑和功能异质性的CAFs种群浸润,它可以直接抑制免疫效应细胞,通过产生大量TGFB1或者下调PVR细胞(NK细胞受体之一)粘附性,抑制NK细胞功能。 原文链接: https://pubmed.ncbi.nlm.nih.gov/36319998/#:~:text=NK%20cells%20and%20solid%20tumors%3A%20therapeutic%20potential%20and,have%20recently%20attra...
此外,肿瘤相关的成纤维细胞、巨噬细胞、骨髓源性抑制细胞和调节性T细胞也可抑制NK细胞依赖的抗肿瘤免疫。2022年11月,Andreas Lundqvist等研究者于Molecular Cancer发表的一篇综述《NK cells and solid tumors: therapeutic potential and persisting obstacles》,回顾了TME的代谢和免疫特征,以及这些特征如何阻止NK细胞持续在...
本文是针对论文《NK细胞和实体瘤:治疗潜力和持续存在的障碍(NK cells and solid tumors: therapeutic potential and persisting obstacles)》该综述于2022年11月发表于Molecular Cancer。 背景介绍 前言:自然杀伤(NK)细胞是具有强大细胞毒性活性的先天性淋巴细胞,它作为潜在的抗癌疗法引起关注,但NK细胞输注在实体瘤患者中...
While NK cells mediate encouraging responses in patients with leukemia, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. Preclinical and clinical data suggest that the efficacy of NK cell infusion against solid malignancies is hampered by several factors ...
4. CAR-NK Cells: From Natural Basis to Designfor Kill. Front Immunol, 2021.5. NK cells and solid tumors: therapeutic potential and persisting obstacles. Mol Cancer, 2022 6. Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in ...
1. Tong, L., Jiménez-Cortegana, C., Tay, A.H. et al. NK cells and solid tumors: therapeutic potential and persisting obstacles. Mol Cancer 21, 206 (2022). https://doi.org/10.1186/s12943-022-01672-z 2. Wang, X., Yang, X., Yuan,...
研究结果于5月24日发表在期刊《iScience》上,题为“Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors”,IF:5.458。 研究背景 嵌合抗原受体(CAR)-T细胞,通过将识别肿瘤相关抗原(TAA)的单链抗体(scFv)和胞内信号域“免疫受体酪氨酸活化基序...
Since the first studies, the mouse models have provided crucial support for the most important discoveries on NK cells, on their development, function, and circulation within normal and tumor tissues. Murine tumor models were initially set to study murine NK cells, then,...