NK cell (pink) attacking tumor cell (green). Sources: Nature (Credit: Eye of science/SPL) 自然 杀伤细胞(NK) 自然杀伤细胞(NK)是机体内负责杀伤肿瘤等异常细胞最主要的“战士”,NK细胞可非特异性直接杀伤肿瘤细胞,且无MHC限制。因此近年来基于NK的过继性细胞疗法被广泛应用于通用型细胞治疗产品的研究。但...
NK细胞全称自然杀伤细胞(natural killer cell,NK cell),是机体先天免疫系统的重要组成部分,占人体所有循环淋巴细胞的15%,具有细胞毒性和免疫调节双重功能。一般我们将人体内CD3-CD56+淋巴细胞认定为NK细胞,根据细胞上CD56的表达水平差异,人类NK细胞可以进一步划分为CD16+CD56dim和CD16-CD56bright两个亚群。CD16+CD56dim...
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice. Analyses of this interplay in human tumor samples...
Cell 162, 1229–1241 (2015). CAS PubMed PubMed Central Google Scholar Gemta, L. F. et al. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Sci. Immunol. 4, eaap9520 (2019). CAS PubMed PubMed Central Google Scholar Ma, C. et...
Greenberg AH, Hudson L, Shen L, Roitt IM. Antibody-dependent cell mediated cytotoxicity due to a “Null” Lymphoid Cell. Nat New Biol. 1973; 242:111–3 Beatriz Cózar et al,Tumor-infiltrating natural killer cells,Cancer Discov. 2021 January 01; 11(1): 34–44....
Environmental obstacles against optimal NK cell activity in solid tumors. For optimal anticancer effects, adoptively transferred natural killer (NK) cells must (1) access and abundantly infiltrate the tumor microenvironment, (2) persist and proliferate therein in the context of preserved NK cell-activa...
与T 细胞相比,NK 细胞(natural killer cell,自然杀伤细胞)是机体重要的先天免疫细胞,无需预敏即可杀伤肿瘤细胞。随着 NK 细胞疗法研究进展加速,有业内人士认为,未来 NK 细胞疗法有可能超越 CAR-T 细胞疗法,对血液瘤和实体瘤呈现出更有前景的疗效。CAR-NK 有望成为继...
Natural killer (NK) cells are innate lymphoid cells with strong cytolytic function to identify and kill tumor cells directly without antigen presentation, which is different to the other adaptive immune cells such as T cells and B cells [1]. In addition, NK cells lack surface T cell receptors...
Different from NK cells, helper ILC (ILC1, ILC2 and ILC3), the innate counterpart of T helper cell subsets, remain rather ambiguous with respect to their anti-tumor activity. A possible exception is represented by a subset of ILC3: their frequency in peri-tumoral tissues in patients with ...
自然杀伤细胞(Natural killer cell,NK细胞 ),是除 T细胞、B细胞之外的第三大类淋巴细胞,不仅与抗肿瘤、抗病毒感染和免疫调节有关,甚至参与超敏反应和自身免疫性疾病的发生。 NK细胞不仅是直接参与肿瘤监测的先天效应淋巴细胞,而且是抗肿瘤CD8+T细胞反应的重要助手。然而,调控NK细胞辅助功能的分子机制和潜在检查点尚不...