NK Cell Killing Strategies for Immunotherapy Several strategies aim to improve tumor reduction via NK cell killing: Enhancing NK cell killing performance by augmenting NK cell function Antibody-dependent cellular cytotoxicity (ADCC) NK cell engagement via bi-specific molecules Increasing the number of NK...
The qualified NK cells are intravenously infused to tumor patients to prevent recurrence and metastasis of cancer cells of the tumor patients. The hematopoietic stem cells used by the method have the advantages of abundant source, material object storage and the like, are free from toxic and side...
Here the authors overcome the immunosuppression of AML-targeted CAR33-NK cells via non-viral CRISPR-editing of the immune checkpoint NKG2A, leading to an enhanced potency of the CAR-NK cell product with sustained anti-tumor efficacy. Tobias Bexte Nawid Albinger Evelyn Ullrich ResearchOpen ...
相关研究结果于2020年11月23日在线发表在PNAS期刊上,论文标题为“Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells”。 肿瘤相关巨噬细胞在肿瘤发生中的主要作用。图片来自Journal of Biomedical Science, 2019, doi:10.1186/s12929-019-0568-z。 ...
Figure 7. BH3 mimetics synergize with pre-activated NK cells in reducing tumor burden and prolonging mouse survival 最后在补充材料中,作者提出这种联用策略对于T细胞治疗来说也同样适用。 参考文献 Pan R, Ryan J, Pan D, et al. Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosi...
Cell 162, 1229–1241 (2015). CAS PubMed PubMed Central Google Scholar Gemta, L. F. et al. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Sci. Immunol. 4, eaap9520 (2019). CAS PubMed PubMed Central Google Scholar Ma, C. et...
基于自然杀伤细胞(NK cell)的免疫疗法是该领域研究的前沿。NK细胞存在于人体天然免疫系统中,是一类细胞毒性淋巴细胞。相较于T细胞,NK细胞不需要组织相容复合物(MHC)为其提供肿瘤抗原,能够自发地检测和杀死受感染细胞或恶性细胞。NK细胞治疗适用于更...
在癌症免疫治疗领域中,CAR-T、TCR-T细胞疗法一直是炙手可热的明星选手,但这些疗法的焦点都集中在T细胞身上。但事实上,除了T细胞外,人体中还存在一类特殊的免疫细胞——即“抗癌先锋”NK细胞,它自带能识别癌细胞、感染细胞的“天赋异禀...
In contrast, NK cell-mediated rejection of MCA-102-E1A tumor cells was not inhibited by the expression of H-2D(d) molecules, nor was killing by polyclonal populations of NK cells isolated from C57BL/6-nude mice. H-2D(d) interacts with several inhibitory Ly49 receptors that are non-...
npg 1351 and involved in NK target cell recognition [12, 13]. Most studies show that the process of NK killing or entering tumor cells can be separated into three steps, conjugating with target cells, internalization (cell-in-cell process) and initiating killing/executing immuno-mod- ulation ...