Natural killer (NK) cells play critical roles in host immunity against cancer. In response, cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current NK cell-based cancer immunotherapy aims to overcome NK cell paralysis using several approaches. One approach uses exp...
The role of IL-13 and NK T cells in experimental and human ulcerative colitis Recent studies that have evaluated the immunologic factors which mediate the development of the two forms of IBD, namely Crohn's disease and ulcerative col... IJ Fuss,W Strober - 《Mucosal Immunology》 被引量: ...
The expression of certain genetic patterns in NK cells or tumor cells can affect brain tumor recurrence and aggressiveness. Silencing ofKLRC3in NK cells, decreases the self-renewal capacity, invasion, proliferation, radio-resistance, and tumorigenicity of the U87-MG glioma cell line52. CRISPR-Cas9-...
NK cells recognize target cells via a major histocompatibility complex (MHC)-independent mechanism and, without being sensitized, kill the cells directly. Several strategies for obtaining large quantities of NK cells with high purity and high cytotoxicity have been...
Human Glioma stemlike cells are better killed by YT-Indy NK cells.Esen Yonca, BassoyValentina, ChiusoloGuillaume, JacqueminCristina, RiccadonnaPaul, R. WalkerDenis, Martinvalet
Usurping activities of TIGIT and CD73 promotes the function of adoptively transferred NK cells into intracranial patient-derived models of glioblastoma and enhances their natural cytolytic functions against this tumor to result in complete tumor eradication. In addition, targeting both receptors, in turn...
CAR-NK cells may have advantages over CAR-T cells, such as less induced side effects. In this context, recent studies have shown that CAR-NK cells did not cause any associated cytokine storm in patients with tumors, which makes the NK cell-based tumor immunotherapy very attractive and ...
近日,来自Dana-Farber肿瘤研究所的Kai W. Wucherpfennig团队及其合作团队在Cell杂志上发表题为Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis的文章。该研究绘制了弥漫性胶质瘤浸润T细胞图谱,并发现了肿瘤T细胞能够表达NK抑制性受体CD161。
9.Sci Transl Med(17.1)| 2024.03.20 | Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly.(重新激活 PTEN 通过抑制胞质铁-硫簇来损害神经胶质瘤干细胞) 胶质瘤干细胞(GSC)不仅可以启动和维持...
Based on the importance of NK cells in anti-PDAC, there is a need to explore the expression profile and the ability of immunotherapy prediction of NK cells. “The fundamental operative unit of a cancer is the genetically and epigenetically innovative single cell”19. The scRNA-seq technique ...